P53 IMMUNOREACTIVITY IN ASTROCYTOMAS AND ITS RELATIONSHIP TO SURVIVAL

被引:36
作者
ALSARRAJ, S [1 ]
BRIDGES, LR [1 ]
机构
[1] LEEDS GEN INFIRM,DEPT PATHOL,NEUROPATHOL LAB,LEEDS,W YORKSHIRE,ENGLAND
关键词
P53; PROTEIN; GENE; IMMUNOHISTOCHEMISTRY; ASTROCYTOMA; SURVIVAL;
D O I
10.1080/02688699550041476
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
p53 is a putative tumour suppressor gene implicated in a wide range of human malignancies. Mutation of p53 gene results in a more stable product and increased quantities of p53 protein in the cell. Thus, unlike the normal situation, mutated p53 is detectable by immunohistochemistry. We stained frozen sections of 74 astrocytomas with two antibodies to p53, PAb 1801 and PAb 421. Overall 18/74 (24%) of astrocytomas showed p53 immunoreactivity. Fifteen of 47 (32%) grade IV were p53 immunopositive, as were 3/16 (19%) grade III, 0/7 (0%) grade II and 0/4 (0%) grade I astrocytomas. These findings are in agreement with previous studies in showing relatively greater numbers of high grade than low grade p53 immunopositive rumours. Although we found an expected difference in survival according to grade, there was no significant difference in survival (p > 0.1) between p53 immunopositive and immunonegative rumours. We conclude that, whilst p53 undoubtedly plays an important role in the molecular 'chain' leading to malignancy in some astrocytomas, within rumours of comparable grade it does not appear to influence survival.
引用
收藏
页码:143 / 149
页数:7
相关论文
共 33 条
[1]  
BAKER SJ, 1990, SCIENCE, V2219, P912
[2]   ISOLATION OF HUMAN-P53-SPECIFIC MONOCLONAL-ANTIBODIES AND THEIR USE IN THE STUDIES OF HUMAN P53 EXPRESSION [J].
BANKS, L ;
MATLASHEWSKI, G ;
CRAWFORD, L .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 159 (03) :529-534
[3]   P53 PROTEIN EXPRESSION IN CENTRAL-NERVOUS-SYSTEM NEOPLASMS [J].
BARBARESCHI, M ;
IUZZOLINO, P ;
PENNELLA, A ;
ALLEGRANZA, A ;
ARRIGONI, G ;
PALMA, PD ;
DOGLIONI, C .
JOURNAL OF CLINICAL PATHOLOGY, 1992, 45 (07) :583-586
[4]  
BARTEK J, 1990, ONCOGENE, V5, P893
[5]  
BRUNER JM, 1991, MODERN PATHOL, V4, P671
[6]   P53 EXPRESSION IN BREAST-CANCER [J].
CATTORETTI, G ;
RILKE, F ;
ANDREOLA, S ;
DAMATO, L ;
DELIA, D .
INTERNATIONAL JOURNAL OF CANCER, 1988, 41 (02) :178-183
[7]  
Crawford L V, 1984, Mol Biol Med, V2, P261
[8]   EXPRESSION OF THE P53 PROTEIN IN A SPECTRUM OF ASTROCYTIC TUMORS [J].
ELLISON, DW ;
GATTER, KC ;
STEART, PV ;
LANE, DP ;
WELLER, RO .
JOURNAL OF PATHOLOGY, 1992, 168 (04) :383-386
[9]   ACTIVATING MUTATIONS FOR TRANSFORMATION BY P53 PRODUCE A GENE-PRODUCT THAT FORMS AN HSC70-P53 COMPLEX WITH AN ALTERED HALF-LIFE [J].
FINLAY, CA ;
HINDS, PW ;
TAN, TH ;
ELIYAHU, D ;
OREN, M ;
LEVINE, AJ .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (02) :531-539
[10]   THE P53 PROTO-ONCOGENE CAN ACT AS A SUPPRESSOR OF TRANSFORMATION [J].
FINLAY, CA ;
HINDS, PW ;
LEVINE, AJ .
CELL, 1989, 57 (07) :1083-1093