MOLECULAR AND BIOCHEMICAL FEATURES OF POLY (ADP-RIBOSE) METABOLISM

被引：289

作者：

LAUTIER, D

LAGUEUX, J

THIBODEAU, J

MENARD, L

POIRIER, GG

机构：

[1] CHUL, RES CTR, POLY%ADP-RIBOSE< METAB LAB, 2705 LAURIER BLVD, ST FOY G1V 4G2, PQ, CANADA

[2] UNIV PERPIGNAN, CHIMIEPHYS LAB, F-66026 PERPIGNAN, FRANCE

[3] INST RECH CLIN MONTREAL, MONTREAL H2W 1R7, QUEBEC, CANADA

[4] DUKE UNIV, MED CTR, DURHAM, NC 27710 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1993年 / 122卷 / 02期

关键词：

CELL TRANSFORMATION; CHROMATIN; DNA REPAIR; DNA REPLICATION; POLY(ADP-RIBOSE); ZN FINGER MOTIF;

D O I：

10.1007/BF01076101

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the past five years, poly(ADP-ribosyl)ation has developed greatly with the help of molecular biology and the improvement of biochemical techniques. In this article, we describe the physico-chemical properties of the enzymes responsible for the synthesis and degradation of poly(ADP-ribose), respectively poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase. We then discuss the possible roles of this polymer in DNA repair and replication as well as in cellular differentiation and transformation. Finally, we put forward various hypotheses in order to better define the function of this polymer found only in eucaryotes.

引用

页码：171 / 193

页数：23

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