DEMOSTRATION OF 2 GAMMA-GLOBULIN SUBCLASSES IN GOAT

Two γ-globulin subclasses, designated γG1 and γG2, have been identifed in goat serum. With similar sedimentation coefficients (6·4 S20,ω), goat γG1 and γG2 have both common and distinct antigenic determinants. The identification of the two subclasses was made possible by the use of rat and guinea pig antisera which reacted against both the common and individual determinants, in contrast to rabbit antisera, which detected only the common antigenic determinants. The existence of the two subclasses may be important in view of the wide-spread use and commercial availability of goat globulin preparations. © 1969.