PHARMACOKINETICS OF HYDROCHLOROTHIAZIDE IN PATIENTS WITH CONGESTIVE HEART-FAILURE

被引：35

作者：

BEERMANN, B ^{[1
]}

GROSCHINSKYGRIND, M ^{[1
]}

机构：

[1] SERAFIMER HOSP,CLIN PHARMACOL LAB,S-11283 STOCKHOLM,SWEDEN

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 7卷 / 06期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb04646.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Hydrochlorothiazide (HCT, 50‐75 mg) was administered orally to seven patients with cardiac failure. 2. Plasma levels and urinary concentration of HCT were determined by GLC. 3. The gastrointestinal uptake of the diuretic in three patients was reduced to approximately half that seen in healthy controls. 4. Plasma halflife of HCT was correlated with endogenous creatinine clearance. 5. Pharmacokinetics of HCT are considerably changed in cardiac failure. 1979 The British Pharmacological Society

引用

页码：579 / 583

页数：5

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