HLA ANTIGENS AND TRANSITIONAL CELL-CARCINOMA OF THE BLADDER

被引：6

作者：

ERYIGIT, M

KIRKALI, Z

机构：

[1] Department of Urology, Gülhanc Military Academy, Ankara

来源：

UROLOGIA INTERNATIONALIS | 1990年 / 45卷 / 02期

关键词：

Bladder tumors; HLA antigens; Major histocompatibility complex; Transitional cell carcinoma;

D O I：

10.1159/000281673

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A possible association between HLA antigens and transitional cell carcinoma of the bladder was searched for in 56 patients and 200 healthy kidney donors. Statistical analysis showed that HLA antigens A23, A25, A28, Bw4, Bw2i, Bw22 and Cw4 are more common in bladder tumor patients, whereas B27 and Bw6 were more common in the control group. The relative risk for HLA Cw4 was 2.07 (95% confidence interval 1.51-2.48). Except for Cw4, these findings are inconsistent with previous reports. We believe this to be due to various misleading factors, and thus not conclusive. Even if such a statistical association exists, this appears to be clinically not relevant and, therefore, should not alter standard practice. © 1990 S. Karger AG, Basel.

引用

页码：75 / 77

页数：3

共 14 条

[1]

Svejgaard A., Platz P., Ryder L.P., HLA and disease 1982, A Survey. Immunol Rev, 70, pp. 193-218, (1983)

[2]

Takasugi M., Terasaki P.I., Hedersson B., Et al., HLA antigens in solid tumours, Cancer Res, 33, pp. 648-650, (1973)

[3]

Arce S., Lopez R., Almaguer M., Et al., HLA antigens and transitional cell carcinoma of the bladder, Mater Med Pol, 35, pp. 98-100, (1978)

[4]

Braf Z.F., Gazit E., Many M., HLA-A and HLA-B antigens in transitional cell carcinoma of the bladder, J Urol, 122, pp. 465-466, (1979)

[5]

Terasaki P.I., Perdue S.T., Mickey M.D., HLA frequencies in cancer. A second study, Genetics of Human Cancer, pp. 321-328, (1977)

[6]

Herring D.W., Cartwright R.A., Williams D., Genetic association of transitional cell carcinoma, Br J Urol, 51, pp. 73-77, (1979)

[7]

Lytton B., O'Toole C., Tiptaft R., Et al., Histocompatibility testing in patients with carcinoma of the bladder, Cancer, 52, pp. 645-647, (1983)

[8]

Akdas A., Tokup R., Ozerkan K., Et al., Association between HLA antigens and bladder tumours, Eur Urol, 13, pp. 207-209, (1987)

[9]

Terasaki P.I., Bernoco D., Parks M.S., Et al., Microdroplet testing for HLA- A, B, C and D, Am J Clin Pathol, 69, pp. 103-106, (1978)

[10]

Green A., The epidemiological approach to studies of association between HLA and disease. II. Estimation of absolute risk, enologie and preventive fraction, Tissue Antigens, 19, pp. 245-258, (1982)

← 1 2 →