THE SYNTHESIS OF 2 NOVEL RING EXPANDED XANTHINE NUCLEOSIDES CONTAINING THE IMIDAZO[4,5-E][1,4]DIAZEPINE RING-SYSTEM

被引：17

作者：

HOSMANE, RS

BHAN, A

机构：

[1] Laboratory for Chemical Dynamics, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore

来源：

NUCLEOSIDES & NUCLEOTIDES | 1990年 / 9卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319008045208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of two regioisomeric nucleosides, 4,5,7,8- tetrahydro-6H-3- (β-D-ribofuranosyl)imidazo [ 4,5-e ] [ 1,4 ]diazepin-5,8-dione (2) and its 1-glycosyl analogue (3) is reported. They were prepared by ribosydation of the heterocyclic aglycon 4 which in turn was synthesized in three steps from 4(5)-nitroimidazole-5(4)-carboxylic acid (5). Distinction between the two isomers was achieved by an unequivocal synthesis of 2. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：913 / 922

页数：10

共 9 条

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