INJURY INDUCED BY FATTY-ACIDS OR BILE-ACID IN ISOLATED HUMAN COLONOCYTES PREVENTED BY CALCIUM

被引：17

作者：

BUSET, M

GALAND, P

LIPKIN, M

WINAWER, S

FRIEDMAN, E

机构：

[1] MEM SLOAN KETTERING CANC CTR,GASTROENTEROL SERV,BOX 244,1275 YORK AVE,NEW YORK,NY 10021

[2] UNIV LIBRE BRUXELLES,HOSP ERASME,B-1070 BRUSSELS,BELGIUM

来源：

CANCER LETTERS | 1990年 / 50卷 / 03期

关键词：

bile acids; calcium; colonic epithelium; fatty acids;

D O I：

10.1016/0304-3835(90)90269-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Measurement of the modulation of the growth fraction of isolated normal colonocytes from adult subjects in primary monolayer culture was used as a sensitive quantitative assay to evaluate toxic effects of several endogenous compounds found within the colon. This assay was used to study the role of CaCl2 in blocking cell injury. When added simultaneously with the injurious agent, 5-10 mM CaCl2 blocked the toxicity of physiological concentrations of deoxycholic acid, oleic acid, palmitic acid and lineoleic acid. © 1990.

引用

页码：221 / 226

页数：6

共 13 条

[1] INHIBITION OF INTESTINAL CARCINOGENESIS BY DIETARY SUPPLEMENTATION WITH CALCIUM [J].