INTRAHEPATIC EXPRESSION OF PRE-S1 AND PRE-S2 ANTIGENS IN CHRONIC HEPATITIS-B VIRUS-INFECTION IN RELATION TO HEPATITIS-B VIRUS-REPLICATION AND HEPATITIS DELTA VIRUS SUPERINFECTION

被引:8
作者
CHU, CM [1 ]
LIAW, YF [1 ]
机构
[1] CHANG GUNG MED COLL, TAIPEI, TAIWAN
关键词
D O I
10.1136/gut.33.11.1544
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatocyte expression of pre-S1 and pre-S2 in relation to hepatitis B virus replication (hepatitis B virus-DNA in serum and HBcAg in the liver), histological activity and hepatitis delta virus superinfection was studied by indirect immunofluorescence on frozen sections of liver specimens from 68 patients with chronic hepatitis B virus infection. All 44 patients with chronic type B hepatitis had pre-S1 and pre-S2 display in the liver. The distribution of pre-S1 in the liver was membranous in one, mixed membranous and cytoplasmic in 12, and cytoplasmic in 31. The distribution of pre-S2 was membranous in one, mixed membranous and cytoplasmic in 26, and cytoplasmic in 17. Membranous expression of pre-S1 was significantly more prevalent in patients with active hepatitis B vims replication than in those without (13/28 v 0/16, p<0.001), regardless of the histological activity, as was membranous expression of pre-S2 (27/28 v 0/16, p<0.001). In contrast, a significantly higher extent of cytoplasmic expression of pre-S1 and pre-S2 was noted in patients without active hepatitis B virus replication than in those with. Of 24 patients with chronic type D hepatitis virus, eight had active hepatitis B virus replication, and the other 16 did not. The distribution and quantitative expression of pre-S1 and pre-S2 in the liver in these patients also correlated significantly with the status of hepatitis B virus replication and, moreover, showed little or no difference from those without hepatitis delta virus infection. In conclusion, all patients with chronic type B hepatitis had synthesis and display of pre-S1 and pre-S2 in the liver. The distribution and quantitative expression of pre-S1 and pre-S2, however, were closely related to the status of hepatitis B virus replication, but not to the histological activity. Hepatocyte expression of pre-S1 and pre-S2 in chronic type D hepatitis also correlated significantly with status of hepatitis B virus replication, and was not modulated by concurrent hepatitis delta virus infection.
引用
收藏
页码:1544 / 1548
页数:5
相关论文
共 34 条
[1]  
[Anonymous], 1977, LANCET, V2, P914
[2]   SIGNALS REGULATING HEPATITIS-B SURFACE-ANTIGEN TRANSCRIPTION [J].
CATTANEO, R ;
WILL, H ;
HERNANDEZ, N ;
SCHALLER, H .
NATURE, 1983, 305 (5932) :336-338
[3]   Intrahepatic Distribution of Hepatitis B Surface and Core Antigens in Chronic Hepatitis B Virus Infection Hepatocyte With Cytoplasmic/Membranous Hepatitis B Core Antigen as a Possible Target for Immune Hepatocytolysis [J].
Chu, Chia-Ming ;
Liaw, Yun-Fan .
GASTROENTEROLOGY, 1987, 92 (01) :220-225
[4]   INTRAHEPATIC EXPRESSION OF HBCAG AND DELTA-ANTIGEN IN ANTI-HBE POSITIVE HBSAG-CARRIERS WITH ACUTE EXACERBATION OR CHRONIC ACTIVE LIVER-DISEASE [J].
CHU, CM ;
LIAW, YF ;
SHEEN, IS ;
CHEN, TJ .
JOURNAL OF MEDICAL VIROLOGY, 1990, 30 (03) :181-186
[5]   HEPATIC EXPRESSION PATTERNS OF THE LARGE AND MIDDLE HEPATITIS-B VIRUS SURFACE-PROTEINS IN VIREMIC AND NONVIREMIC CHRONIC HEPATITIS-B [J].
DIENES, HP ;
GERLICH, WH ;
WORSDORFER, M ;
GERKEN, G ;
BIANCHI, L ;
HESS, G ;
ZUMBUSCHENFELDE, KHM .
GASTROENTEROLOGY, 1990, 98 (04) :1017-1023
[6]   EXPRESSION OF PRES1 AND PRES2 IN THE LIVER OF CHRONIC HEPATITIS-B VIRUS CARRIERS [J].
FRAIESE, A ;
PONTISSO, P ;
CAVALLETTO, D ;
FATTOVICH, G ;
ALBERTI, A .
JOURNAL OF HEPATOLOGY, 1988, 7 (02) :157-163
[7]   PRE-S ENCODED SURFACE-PROTEINS IN RELATION TO THE MAJOR VIRAL SURFACE-ANTIGEN IN ACUTE HEPATITIS-B VIRUS-INFECTION [J].
GERKEN, G ;
MANNS, M ;
GERLICH, WH ;
HESS, G ;
ZUMBUSCHENFELDE, KHM .
GASTROENTEROLOGY, 1987, 92 (06) :1864-1868
[8]   EXPRESSION OF PRE-S GENE-ENCODED PROTEINS IN LIVER AND SERUM DURING CHRONIC HEPATITIS-B VIRUS-INFECTION IN COMPARISON TO OTHER MARKERS OF ACTIVE VIRUS-REPLICATION [J].
HADZIYANNIS, S ;
RAIMONDO, G ;
PAPAIOANNOU, C ;
ANASTASSAKOS, C ;
WONG, D ;
SNINSKY, J ;
SHAFRITZ, D .
JOURNAL OF HEPATOLOGY, 1987, 5 (03) :253-259
[9]   LIVER-DISEASE ACTIVITY AND HEPATITIS-B VIRUS-REPLICATION IN CHRONIC DELTA-ANTIGEN-POSITIVE HEPATITIS-B VIRUS CARRIERS [J].
HADZIYANNIS, SJ ;
SHERMAN, M ;
LIEBERMAN, HM ;
SHAFRITZ, DA .
HEPATOLOGY, 1985, 5 (04) :544-547
[10]   PRE-S1 AND PRE-S2 GENE-ENCODED PROTEINS IN LIVER AND SERUM IN CHRONIC HEPATITIS DELTA INFECTION [J].
HADZIYANNIS, SJ ;
GEORGOPOULOU, U ;
PSALIDAKI, E ;
BUDKOWSKA, A .
JOURNAL OF MEDICAL VIROLOGY, 1991, 34 (01) :14-19