MUCOSAL DELIVERY OF MACROMOLECULES

被引：17

作者：

EBERT, CD ^{[1
]}

HEIBER, SJ ^{[1
]}

DAVE, SC ^{[1
]}

KIM, SW ^{[1
]}

MIX, D ^{[1
]}

机构：

[1] UNIV UTAH,CTR CONTROLLED CHEM DELIVERY,DEPT PHARMACEUT & PHARMACEUT CHEM,SALT LAKE CITY,UT 84108

来源：

JOURNAL OF CONTROLLED RELEASE | 1994年 / 28卷 / 1-3期

关键词：

BUCCAL DELIVERY; TRANSMUCOSAL DELIVERY; LOW MOLECULAR WEIGHT HEPARIN; MUCOSAL ABSORPTION ENHANCER; BILE SALT ENHANCER; PERMEATION ENHANCER;

D O I：

10.1016/0168-3659(94)90151-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Low molecular weight heparin (LMWH), a glycosaminoglycan of approximately 6000 molecular weight, is currently used in the prevention of postsurgical thrombosis and in the treatment of deep vein thrombosis. Current dosing regimens entail subcutaneous injections of 2500-5000 anti-factor X(2) units per day. Transbuccal delivery of LMWH may provide significant advantages over the current injectable dosage forms. The kinetics and extent of LMWH absorption from prototype buccal dosage forms were evaluated. Based on pharmacokinetic analysis, over 3000 anti-factor X(2) units (i.e., 20 mg) could be delivered from a single application. These results demonstrate the feasibility of administering macromolecular drugs, such as LMWH, via the buccal route.

引用

页码：37 / 44

页数：8

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