INCREASED LEVELS OF LEUKOCYTE ELASTASE IN ISCHEMIC STROKE AND IN SUBJECTS WITH VASCULAR RISK-FACTORS

被引：12

作者：

GRAU, AJ ^{[1
]}

SEITZ, R ^{[1
]}

IMMEL, A ^{[1
]}

STEICHENWIEHN, C ^{[1
]}

HACKE, W ^{[1
]}

机构：

[1] UNIV MARBURG,DEPT MED,MARBURG,GERMANY

来源：

CEREBROVASCULAR DISEASES | 1995年 / 5卷 / 01期

关键词：

LEUKOCYTES; ELASTASE; STROKE; VASCULAR RISK FACTORS;

D O I：

10.1159/000107819

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Proteolytic enzymes by polymorphonuclear leukocytes such as elastase may contribute to the pathogenesis of acute cerebral ischemia. We measured elastase al-protease inhibitor complexes (EIC) in acute ischemic stroke and in controls with and without vascular risk factors. Levels of EIC were higher in patients (n = 24, 51.4 +/- 18.5 ng/ml) than in healthy controls (n = 26, 36.2 +/- 11.5 ng/ml, p < 0.001) but not higher than in controls with risk factors (n = 22, 53.4 +/- 29.6 ng/ml). Stroke patients with recent or concomitant infections had higher EIC levels than all other groups (n = 14, 71.0 +/- 24.6 ng/ml). This result suggests leukocyte activation in acute stroke and in subjects with increased risk for stroke.

引用

页码：50 / 54

页数：5

共 28 条

[1] INHIBITION OF THE HUMAN-LEUKOCYTE ENDOPEPTIDASES ELASTASE AND CATHEPSIN G AND OF PORCINE PANCREATIC ELASTASE BY N-OLEOYL DERIVATIVES OF HEPARIN [J].