IL-10 IMMUNOSUPPRESSION IN TRANSPLANTATION

被引：70

作者：

BROMBERG, JS

机构：

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 05期

关键词：

D O I：

10.1016/0952-7915(95)80070-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The description of IL-10 as an immunosuppressive cytokine that inhibits numerous T-cell and antigen-presenting cell functions has led to the investigation of the role of IL-10 in graft acceptance and rejection, in both manipulated and unmanipulated experimental systems. Recent results suggest a complex interaction of IL-10 with other cytokines and numerous cell types. Although IL-10 is not a simple immunosuppressive molecule, manipulation of its actions may be a useful approach for prolonging graft survival and preventing rejection.

引用

页码：639 / 643

页数：5

共 51 条

[1] DIFFERENTIAL CYTOKINE EXPRESSION IN ACUTE AND CHRONIC MURINE GRAFT-VERSUS-HOST-DISEASE
ALLEN, RD
STALEY, TA
SIDMAN, CL
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (02) : 333 - 337
[2] ALLIONE A, 1994, CANCER RES, V54, P6022
[3] BAAN CC, 1994, CLIN EXP IMMUNOL, V97, P293
[4] HIGH-LEVELS OF INTERLEUKIN-10 PRODUCTION IN-VIVO ARE ASSOCIATED WITH TOLERANCE IN SCID PATIENTS TRANSPLANTED WITH HLA MISMATCHED HEMATOPOIETIC STEM-CELLS
BACCHETTA, R
BIGLER, M
TOURAINE, JL
PARKMAN, R
TOVO, PA
ABRAMS, J
MALEFYT, RD
DEVRIES, JE
RONCAROLO, MG
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) : 493 - 502
[5] Bishop G A, 1993, Transpl Immunol, V1, P253, DOI 10.1016/0966-3274(93)90033-5
[6] CHAN SY, 1995, TRANSPLANTATION, V59, P1156
[7] SELECTIVE REGULATION OF ICAM-1 AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I AND CLASS-II MOLECULE EXPRESSION ON EPIDERMAL LANGERHANS CELLS BY SOME OF THE CYTOKINES RELEASED BY KERATINOCYTES AND T-CELLS
CHANG, CH
FURUE, M
TAMAKI, K
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (11) : 2889 - 2895
[8] ENHANCED TYPE-2 AND DIMINISHED TYPE-1 CYTOKINES IN NEONATAL TOLERANCE
CHEN, NX
FIELD, EH
[J]. TRANSPLANTATION, 1995, 59 (07) : 933 - 941
[9] LOCAL PRODUCTION OF CYTOKINES IN THE HUMAN CARDIAC ALLOGRAFT - A SEQUENTIAL STUDY
CUNNINGHAM, DA
DUNN, MJ
YACOUB, MH
ROSE, ML
[J]. TRANSPLANTATION, 1994, 57 (09) : 1333 - 1337
[10] INTERLEUKIN-10 (IL-10) INHIBITS HUMAN LYMPHOCYTE INTERFERON GAMMA-PRODUCTION BY SUPPRESSING NATURAL-KILLER-CELL STIMULATORY FACTOR/IL-12 SYNTHESIS IN ACCESSORY CELLS
DANDREA, A
ASTEAMEZAGA, M
VALIANTE, NM
MA, XJ
KUBIN, M
TRINCHIERI, G
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) : 1041 - 1048

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