EVALUATION OF SELECTED PARAMETERS OF IMMUNE FUNCTION IN ASTHMATICS AFTER LONG-TERM CORTICOSTEROID-THERAPY

被引:9
作者
CHIANG, J
PATTERSON, R
MCGILLEN, J
HARRIS, K
PHAIR, J
ROBERTS, M
RIESING, K
机构
[1] NORTHWESTERN UNIV,SCH MED,DEPT MED,ALLERGY IMMUNOL SECT,CHICAGO,IL 60611
[2] NORTHWESTERN UNIV,SCH MED,DEPT MED,INFECT DIS SECT,CHICAGO,IL 60611
来源
CLINICAL ALLERGY | 1979年 / 9卷 / 04期
关键词
D O I
10.1111/j.1365-2222.1979.tb02499.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The availability of inhaled beclomethasone diproprionate permitted the discontinuation of continuous, long‐term systemic corticosteroid therapy (SCT) in a group of asthmatics who had previously required SCT to control their asthma. Twelve patients had been on SCT for a period of 2–22 years with an average duration of 7 years. To determine whether this previous long‐term SCT and the current use of inhaled beclomethasone diproprionate had an effect on leucocyte functions, a variety of studies reflecting T lymphocyte, B lymphocyte and granulocyte function was done. The results were compared with those of twelve asthmatic patients of similar age ranges who had never received steroids. Results showed that the two patient populations could not be differentiated on the basis of phytohaemagglutinin stimulation of lymphocytes, sheep erythrocyte rosette formation, IgG, IgA, IgM and IgE concentrations or granulocyte bactericidal activity. Delayed skin reactivity was present in both groups, with more positive reactions in the non‐SCT group. Polymorphonuclear adherence values were slightly lower in the SCT female population using beclomethasone diproprionate. The latter two minor differences may be due to the previous SCT, the use of beclomethasone diproprionate or the limited population of patients studied. We conclude from these studies that the long‐term use of SCT at the low doses required for control of asthma resulted in little permanent effect on the variety of lymphocyte and granulocyte functions tested. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码:397 / 410
页数:14
相关论文
共 35 条
[1]   LONG-TERM EFFECTS OF BECLOMETHASONE DIPROPIONATE ON PREDNISONE DOSAGE IN CORTICOSTEROID-DEPENDENT ASTHMATIC [J].
BACAL, E ;
PATTERSON, R .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1978, 62 (02) :72-75
[2]  
BAXTER JD, 1975, TRANSPLANT P, V7, P55
[3]   EFFECT OF 3', 5'-ADENOSINE MONOPHOSPHATE ON GRANULOCYTE ADHESION [J].
BRYANT, RE ;
SUTCLIFFE, MC .
JOURNAL OF CLINICAL INVESTIGATION, 1974, 54 (05) :1241-1244
[4]   EFFECTS OF CORTICOSTEROIDS ON IMMUNITY IN MAN .1. DECREASED SERUM IGG CONCENTRATION CAUSED BY 3 OR 5 DAYS OF HIGH DOSES OF METHYLPREDNISOLONE [J].
BUTLER, WT ;
ROSSEN, RD .
JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (10) :2629-2640
[5]   EFFECT OF ALTERNATE-DAY PREDNISONE ON WHITE BLOOD COUNT IN CHILDREN WITH CHRONIC ASTHMA [J].
CHAI, H ;
GILBERT, A .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1973, 51 (02) :65-70
[6]   CORTICOSTEROID DOSE GRAPH - USE IN DETERMINATION OF CORTICOSTEROID REQUIREMENTS, CHARACTERIZATION OF PATIENTS, AND PREVENTION OF SEASONAL EXACERBATION IN CORTICOSTEROID-DEPENDENT PATIENTS [J].
COOPER, BJ ;
PATTERSON, R .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1976, 58 (06) :635-646
[7]  
COOPER DA, 1977, CLIN EXP IMMUNOL, V28, P467
[8]   ADRENAL GLUCOCORTICOIDS AFTER 20 YEARS . A REVIEW OF THEIR CLINICALLY RELEVANT CONSEQUENCES [J].
DAVID, DS ;
GRIECO, MH ;
CUSHMAN, P .
JOURNAL OF CHRONIC DISEASES, 1970, 22 (10) :637-+
[9]  
FAN PT, 1978, J LAB CLIN MED, V91, P625
[10]   GLUCOCORTICOSTEROID THERAPY - MECHANISMS OF ACTION AND CLINICAL CONSIDERATIONS [J].
FAUCI, AS ;
DALE, DC ;
BALOW, JE .
ANNALS OF INTERNAL MEDICINE, 1976, 84 (03) :304-315