RIFAMPICIN POXVIRUS AND TRACHOMA AGENT

被引：60

作者：

BENISHAI, Z

HELLER, E

GOLDBLUM, N

BECKER, Y

机构：

[1] Department of Virology, Hebrew University, Hadassah Medical School, Jerusalem

来源：

NATURE | 1969年 / 224卷 / 5214期

关键词：

D O I：

10.1038/224029a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rifampicin appears to inhibit the replication of poxvirus by blocking the synthesis of virus protein late in the growth cycle. The antibiotic inhibits the multiplication of trachoma agent in vitro, and in vivo; it has been used successfully to treat trachoma infection of a baboon's eye. The hydrazone side-chain of rifampicin appears to be essential for its anti-viral and anti-trachomal activity. © 1969 Nature Publishing Group.

引用

收藏

页码：29 / &

相关论文

共 21 条

[1] MESSENGER RNA IN CELLS INFECTED WITH VACCINIA VIRUS [J].

BECKER, Y ;

JOKLIK, WK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (04) :577-&

[2] RIFAMPICIN - A NEW ANTITRACHOMA DRUG [J].

BECKER, Y ;

ZAKAYRON.Z .

NATURE, 1969, 222 (5196) :851-&

[3] RIFAMPICIN SENSITIVITY OF COMPONENTS OF DNA-DEPENDENT RNA POLYMERASE [J].

DIMAURO, E ;

SNYDER, L ;

MARINO, P ;

LAMBERTI, A ;

COPPO, A ;

TOCCHINI.GP .

NATURE, 1969, 222 (5193) :533-&

[4]

EASTERBROOK KB, 1962, VIROLOGY, V17, P244

[5] ROLE OF HOST RNA POLYMERASE IN PHAGE DEVELOPMENT [J].

GEIDUSCHEK, EP ;

SKLAR, J ;

HASELKOR.R ;

VOGEL, M ;

BROWN, RD .

NATURE, 1969, 221 (5183) :833-+

[6]

HASELKORN R, 1969, NATURE, V221, P836

[7] SELECTIVE INHIBITION OF VACCINIA VIRUS BY ANTIBIOTIC RIFAMPICIN [J].

HELLER, E ;

ARGAMAN, M ;

LEVY, H ;

GOLDBLUM, N .

NATURE, 1969, 222 (5190) :273-&

[8] STUDIES ON STRUCTURAL PROTEINS OF VACCINIA VIRUS .I. STRUCTURAL PROTEINS OF VIRIONS AND CORES [J].

HOLOWCZA.JA ;

JOKLIK, WK .

VIROLOGY, 1967, 33 (04) :717-&

[9] STUDIES ON STRUCTURAL PROTEINS OF VACCINIA VIRUS .2. KINETICS OF SYNTHESIS OF INDIVIDUAL GROUPS OF STUCTURAL PROTEINS [J].

HOLOWCZAK, JA ;

JOKLIK, WK .

VIROLOGY, 1967, 33 (04) :726-+

[10]

JOKLIK W. K., 1965, J MOL BIOL, V13, P511