ASYMMETRIZED TRIS(HYDROXYMETHYL)METHANE AS A HIGHLY STEREODIVERGENT CHIRAL BUILDING BLOCK - PREPARATION OF ALL 4 STEREOISOMERS OF PROTECTED 2-HYDROXYMETHYL-1,3-BUTANEDIOL

被引：17

作者：

GUANTI, G ^{[1
]}

BANFI, L ^{[1
]}

NARISANO, E ^{[1
]}

机构：

[1] CTR STUDIO DIARILOIDI,CNR,I-16132 GENOA,ITALY

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(00)97081-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Monoacetate 3 is a synthetic equivalent of asymmetrized tris (hydroxymethyl)methane 1, which is a new chiral building block endowed with latent C3v symmetry. Thanks to this property, starling from a single enantiomer 3, it is possible to get not only both (R) and (S) aldehydes 7, but also all the stereoisomers deriving from addition of a C-nucleophile to 7, just relying on a single diastereocontrol (double stereodivergency). © 1990.

引用

页码：6421 / 6424

页数：4

共 17 条

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