THIAZIDE DIURETIC RECEPTORS IN SPONTANEOUSLY HYPERTENSIVE RATS AND 2-KIDNEY 1-CLIP HYPERTENSIVE RATS

被引：20

作者：

BEAUMONT, K ^{[1
]}

VAUGHN, DA ^{[1
]}

CASTO, R ^{[1
]}

PRINTZ, MP ^{[1
]}

FANESTIL, DD ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT PHARMACOL,LA JOLLA,CA 92093

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | 1990年 / 12卷 / 02期

关键词：

Distal Tubule; Diuretics; Drug Receptors; Hypertension; Kidney; SHR; Thiazides;

D O I：

10.3109/10641969009074730

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thiazide diuretic receptor density was assessed in kidneys from spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats by measuring hydroflumethiazide-displaceable 3H-metolazone binding to renal membranes in vitro. Renal thiazide receptor density was not significantly different in 4 week old SHR and WKY rats, but was significantly increased by 20% - 40% in 14 -49 week old SHRs compared to WKY rats. Affinity of receptors for 3H-metolczone did not differ between SHRs and WKY rats at any age. In WKY rats with 2 kidney-1 clip (2K-1C) hypertension, thiazide receptor density was not significantly different in either clipped or unclipped kidneys from sham-operated controls. Thus, increased renal thiazide receptor density occurs in SHRs along with the development of hypertension and does not appear to be secondary to increased renal perfusion pressure. This increase may reflect altered hormonal or ionic input to the distal tubule and may contribute to elevated sodium reabsorption in this segment in the SHR. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：215 / 226

页数：12

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