DIFFERENTIAL EXPRESSION OF A FAMILY OF PUTATIVE ADENYLATE GUANYLATE-CYCLASE GENES IN TRYPANOSOMA-BRUCEI

被引：71

作者：

ALEXANDRE, S ^{[1
]}

PAINDAVOINE, P ^{[1
]}

TEBABI, P ^{[1
]}

PAYS, A ^{[1
]}

HALLEUX, S ^{[1
]}

STEINERT, M ^{[1
]}

PAYS, E ^{[1
]}

机构：

[1] UNIV BRUSSELS,DEPT MOLEC BIOL,67 RUE CHEVAUX,B-1640 RHODE ST GENESE,BELGIUM

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1990年 / 43卷 / 02期

关键词：

Adenylate cyclase; Gene expression; Guanylate cyclase; Parasite life-cycle; Trypanosome;

D O I：

10.1016/0166-6851(90)90152-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression site for the variant surface glycoprotein (VSG) gene of Trypanosoma brucei contains several genes of unknown function (ESAGs, for expression site-associated genes). Among these, ESAG 4 shows homology to eukaryotic adenylate/guanylate cyclase genes, in the region encoding the presumptive enzyme catalytic domain. This gene belongs to a family of related sequences, and hybridizes to the genomic DNA of other trypanosomatids, such as Trypanosoma congolense, Trypanosoma vivax and Trypanosoma mega. While ESAG 4 is transcribed only in bloodstream forms by a RNA polymerase resistant to α-amanitin, at least three other members of this family are transcribed in both bloodstream and procyclic forms, by a RNA polymerase sensitive to the drug. These genes encode different putative transmembrane proteins showing high sequence conservation in the region corresponding to the adenylate/guanylate cyclase catalytic domain. © 1990.

引用

页码：279 / 288

页数：10

共 29 条

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