CROSS-REACTIVE LEGIONELLA ANTIGENS AND THE ANTIBODY-RESPONSE DURING INFECTION

被引：13

作者：

BANGSBORG, JM

SHAND, G

PEARLMAN, E

HOIBY, N

机构：

[1] DAKO A-S,DEPT MICROBIOL,GLOSTRUP,DENMARK

[2] UNIV COPENHAGEN,INST MED MICROBIOL,DK-1168 COPENHAGEN,DENMARK

[3] UNIV MICHIGAN,SCH MED,DEPT MICROBIOL & IMMUNOL,ANN ARBOR,MI 48104

来源：

APMIS | 1991年 / 99卷 / 09期

关键词：

LEGIONELLA; WESTERN BLOT; ANTIBODY RESPONSE;

D O I：

10.1111/j.1699-0463.1991.tb01271.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to define cross-reactive Legionella antigens suitable for diagnostic purposes, we investigated sonicate antigens from two Legionella species, including two serogroups of L. pneumophila. The antigens were reacted with heterologous and homologous rabbit antisera in Western blot. Sera from seven patients with culture-verified L. pneumophila infection and nine patients with serologically confirmed L. micdadei infection were also investigated for reactivity with the corresponding antigens. Among the cross-reactive Legionella antigens defined, non-specific reactivity in patients' sera with the 58-kDa common antigen (CA) was noted. Specific reactions were observed with the Legionella flagellum antigen and with the macrophage infectivity potentiator (Mip) protein; with both antigens, however, the reactive sera were too few to suggest the use of a single antigen in a diagnostic test.

引用

页码：854 / 865

页数：12

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