STUDIES ON THE ROLE OF TUMOR-NECROSIS-FACTOR IN ADULT RESPIRATORY-DISTRESS SYNDROME

被引:78
作者
PARSONS, PE
MOORE, FA
MOORE, EE
IKLE, DN
HENSON, PM
WORTHEN, GS
机构
[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,DENVER,CO
[2] UNIV COLORADO,DEPT SURG,DENVER,CO 80202
[3] UNIV COLORADO,DEPT PATHOL,DENVER,CO 80202
[4] DENVER GEN HOSP,DEPT SURG,DENVER,CO 80204
[5] UNIV COLORADO,DEPT MED,DENVER,CO 80202
[6] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DENVER,CO
来源
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1992年 / 146卷 / 03期
关键词
D O I
10.1164/ajrccm/146.3.694
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Tumor necrosis factor (TNF), rapidly becoming recognized as a mediator of inflammation, may be important in the pathogenesis of acute lung injury. Its role in the development of the adult respiratory distress syndrome (ARDS) in humans, however, had been difficult to clarify. To determine if TNF could be important early in the development of acute lung injury from multiple causes, we enrolled 103 patients within 8 h of meeting the criteria for an at-risk illness (sepsis, aspiration of gastric contents, severe pancreatitis, hypertransfusion, abdominal trauma, chest trauma, multiple fractures) and obtained multiple frequent blood samples for TNF measurements. Using five methods of TNF analysis, we were unable to find an association between TNF and the development of ARDS. However, we found significant differences in TNF measurements depending on the methods of analysis used, which could, at least in part, account for the inconsistencies in the published literature regarding the relationship between TNF and disease processes.
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页码:694 / 700
页数:7
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