COMPARISON OF THE NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF THE ENVELOPE PROTEIN GENES OF THE WILD-TYPE FRENCH VISCEROTROPIC STRAIN OF YELLOW-FEVER VIRUS AND THE LIVE VACCINE STRAIN, FRENCH NEUROTROPIC VACCINE, DERIVED FROM IT

被引：26

作者：

JENNINGS, AD ^{[1
]}

WHITBY, JE ^{[1
]}

MINOR, PD ^{[1
]}

BARRETT, ADT ^{[1
]}

机构：

[1] NATL INST BIOL STAND & CONTROLS,DIV VIROL,POTTERS BAR EN6 3QG,ENGLAND

来源：

VIROLOGY | 1993年 / 192卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1090

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The envelope (E) protein genes of the wild-type yellow fever (YF) virus French viscerotropic virus and its’ vaccine derivative, French neurotropic virus (FNV), were compared and found to differ by 13 nucleotides that coded for 8 amino acid substitutions. Comparison of the E proteins of FNV and 17D, the vaccine strain derived from wild-type strain Asibi, showed that there was no common nucleotide change or amino acid substitution between these two vaccine strains. However, changes are clustered around amino acid positions 52-56 and may represent the common vaccine epitope shared by 17D and FNV vaccine viruses. The molecular basis of any difference in neurotropism and viscerotropism of YF virus, attributable to the E protein, remains unclear. © 1993 Academic Press, Inc.

引用

页码：692 / 695

页数：4

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