Localization of the Murine Leukemia Inhibitory Factor Gene Near the Centromere on Chromosome 11

被引：28

作者：

Kola, Ismail ^{[1
]}

Davey, Anna ^{[1
,3
]}

Gough, Nicholas M. ^{[2
]}

机构：

[1] Monash Med Ctr, Ctr Early Human Dev, Clayton, Vic 3168, Australia

[2] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Post Off, Parkville, Vic 3050, Australia

[3] State Forens Sci Lab, Yallambie, Vic 3085, Australia

来源：

GROWTH FACTORS | 1990年 / 2卷 / 02期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

leukemia inhibitory factor (LIF); DIA; D-factor; ES cells; EC cells;

D O I：

10.3109/08977199009071509

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Leukemia inhibitory factor (LIF) is a glycoprotein with divergent activities: It induces the differentiation of certain myeloid leukemic cells, inhibits the differentiation of embryonic stem cells, and promotes bone remodelling in viuo and in vitro. The murine LIF gene has been assigned to the proximal region of chromosome 11 at sub-bands A1-A2, by analysis of a panel of mouse x Chinese hamster somatic cell hybrids and by in situ hybridization. Interestingly, the proximal portion of chromosome 11 has been shown, by virtue of its parental origin effects, to contain gene(s) involved in fetal growth. It is also interesting that there is a preponderance of chromosome 11 abnormalities in embryonal carcinoma cells. The localization of the murine LIF gene confirms the homology of a portion of murine chromosome 11 with human chromosome 22q, the site of the human LIF gene.

引用

页码：235 / 240

页数：6

共 23 条

[1] DIFFERENTIATION-INDUCING FACTOR PURIFIED FROM CONDITIONED MEDIUM OF MITOGEN-TREATED SPLEEN-CELL CULTURES STIMULATES BONE-RESORPTION
ABE, E
TANAKA, H
ISHIMI, Y
MIYAURA, C
HAYASHI, T
NAGASAWA, H
TOMIDA, M
YAMAGUCHI, Y
HOZUMI, M
SUDA, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) : 5958 - 5962
[2] ASSIGNMENT OF HUMAN TRANSCOBALAMIN-II (TC2) TO CHROMOSOME-22 USING SOMATIC-CELL HYBRIDS AND MONOSOMIC MENINGIOMA CELLS
ARWERT, F
PORCK, HJ
FRATERSCHRODER, M
BRAHE, C
VANKESSEL, AG
WESTERVELD, A
KHAN, PM
ZANG, K
FRANTS, RR
KORTBEEK, HT
ERIKSSON, AW
[J]. HUMAN GENETICS, 1986, 74 (04) : 378 - 381
[3] CLOSE GENETIC AND PHYSICAL LINKAGE BETWEEN THE MURINE HEMATOPOIETIC GROWTH-FACTOR GENES GM-CSF AND MULTI-CSF (IL3)
BARLOW, DP
BUCAN, M
LEHRACH, H
HOGAN, BIM
GOUGH, NM
[J]. EMBO JOURNAL, 1987, 6 (03) : 617 - 623
[4] DIFFERENTIAL ACTIVITY OF MATERNALLY AND PATERNALLY DERIVED CHROMOSOME REGIONS IN MICE
CATTANACH, BM
KIRK, M
[J]. NATURE, 1985, 315 (6019) : 496 - 498
[5] FUSION OF DNA REGION TO MURINE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS CORRESPONDS TO PLASMACYTOMA-ASSOCIATED CHROMOSOME-TRANSLOCATION
CORY, S
ADAMS, JM
GERONDAKIS, SD
MILLER, JFAP
GAMBLE, J
WIENER, F
SPIRA, J
FRANCKE, U
[J]. EMBO JOURNAL, 1983, 2 (02) : 213 - 216
[6] EIBERG H, 1986, CLIN GENET, V29, P354
[7] GENE MAPPING IN MUS-MUSCULUS BY INTERSPECIFIC CELL HYBRIDIZATION - ASSIGNMENT OF GENES FOR TRIPEPTIDASE-1 TO CHROMOSOME-10, DIPEPTIDASE-2 TO CHROMOSOME-18, ACID PHOSPHATASE-1 TO CHROMOSOME-12, AND ADENYLATE KINASE-1 TO CHROMOSOME-2
FRANCKE, U
LALLEY, PA
MOSS, W
IVY, J
MINNA, JD
[J]. CYTOGENETICS AND CELL GENETICS, 1977, 19 (2-3): : 57 - 84
[8] LOCALIZATION OF THE GENE FOR THE VITAMIN-B12 BINDING-PROTEIN, TRANSCOBALAMIN-II, NEAR THE CENTROMERE ON MOUSE CHROMOSOME-11, LINKED WITH THE HEMOGLOBIN ALPHA-CHAIN LOCUS
FRATERSCHRODER, M
PROCHAZKA, M
HALLER, O
ARWERT, F
PORCK, HJ
SKOW, LC
LUNDIN, LG
HILKENS, J
HILGERS, J
[J]. BIOCHEMICAL GENETICS, 1985, 23 (1-2) : 139 - 153
[9] MOLECULAR-CLONING AND EXPRESSION OF CDNA-ENCODING A MURINE MYELOID-LEUKEMIA INHIBITORY FACTOR (LIF)
GEARING, DP
GOUGH, NM
KING, JA
HILTON, DJ
NICOLA, NA
SIMPSON, RJ
NICE, EC
KELSO, A
METCALF, D
[J]. EMBO JOURNAL, 1987, 6 (13) : 3995 - 4002
[10] MOLECULAR-CLONING AND EXPRESSION OF THE HUMAN HOMOLOG OF THE MURINE GENE ENCODING MYELOID LEUKEMIA-INHIBITORY FACTOR
GOUGH, NM
GEARING, DP
KING, JA
WILLSON, TA
HILTON, DJ
NICOLA, NA
METCALF, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) : 2623 - 2627

← 1 2 3 →