SYNTHESIS OF POLYMER-BOUND 6-THIOLATOMERCURY AND 6-MERCURIC SULFONATE DOPA PRECURSORS AND THEIR HALODEMERCURATION REACTIVITY

被引：6

作者：

KAWAI, K ^{[1
]}

CHANNING, MA ^{[1
]}

KIESEWETTER, DO ^{[1
]}

ECKELMAN, WC ^{[1
]}

机构：

[1] NIH,WARREN GRANT MAGNUSON CLIN CTR,DEPT PET,BETHESDA,MD 20892

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1995年 / 22卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0969-8051(94)00079-Y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Fluorodemercuration has the greatest utility for the preparation of 6-[F-18]DOPA, but requires separation from unreacted mercury precursor and other mercury-containing compounds. One approach is the development of a polymer-bound mercury precursor. Tn this study, polymer-bound 6-thiolatomercury and 6-mercuric sulfonate DOPA derivatives, and its monomeric analogs were synthesized. Fluorodemercuration of monomeric analog of mercuric sulfonate gave half the yield (14-15%) while iododemercuration gave the same yield (38%) compared with a 6-mercuric trifluoroacetate protected DOPA. The mercuric sulfonate undergoes halodemercuration, so polymer-bound halodemercuration precursors may be useful as precursors of 6-[F-18]DOPA.

引用

页码：37 / 43

页数：7

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