BETA-ADRENERGIC RECEPTORS OF HUMAN-LYMPHOCYTES ARE UNALTERED BY HYPER-THYROIDISM

被引：68

作者：

WILLIAMS, RS ^{[1
]}

GUTHROW, CE ^{[1
]}

LEFKOWITZ, RJ ^{[1
]}

机构：

[1] DUKE UNIV, MED CTR, DEPT MED, DIV CARDIOVASC DIS, DURHAM, NC 27710 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 48卷 / 03期

关键词：

D O I：

10.1210/jcem-48-3-503

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lymphocytes from 12 patients with untreated hyperthyroidism were compared to lymphocytes from age-and sex-matched euthyroid control subjects to test the hypothesis that alterations in β-adrenergic response mechanisms occur in human hyperthyroidism. The binding of (—)[3H]dihydroalprenolol, a compound previously shown in these cells to label binding sites having the characteristics of β-adrenergic receptors, was assayed and no significant difference was found between the two groups. In addition, the accumulation of cAMP in response to isoproterenol was determined by RIA and, again, no difference was found. © 1979 by The Endocrine Society.

引用

页码：503 / 505

页数：3

共 10 条

[1] BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[2] HARPER JF, 1975, J CYCLIC NUCL PROT, V1, P207
[3] RECEPTORS FOR PEPTIDE HORMONES - NEW INSIGHTS INTO PATHOPHYSIOLOGY OF DISEASE STATES IN MAN
KAHN, CR
MEGYESI, K
BAR, RS
EASTMAN, RC
FLIER, JS
[J]. ANNALS OF INTERNAL MEDICINE, 1977, 86 (02) : 205 - 219
[4] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[5] MALBON CC, 1978, J BIOL CHEM, V253, P671
[6] ALTERATIONS IN CYCLIC ADENOSINE-MONOPHOSPHATE METABOLISM IN HUMAN BRONCHIAL-ASTHMA .1. LEUKOCYTE RESPONSIVENESS TO BETA-ADRENERGIC AGENTS
PARKER, CW
SMITH, JW
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (01) : 48 - 59
[7] HORMONE RESISTANCE AND HORMONE SENSITIVITY
ROTH, J
NEVILLE, DM
KAHN, CR
GORDEN, P
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1977, 296 (05) : 277 - 278
[8] STEINER AL, 1972, J BIOL CHEM, V247, P1106
[9] IDENTIFICATION OF BETA-ADRENERGIC RECEPTORS IN HUMAN LYMPHOCYTES BY (ALPRENOLOL-H-3] BINDING
WILLIAMS, LT
SNYDERMAN, R
LEFKOWITZ, RJ
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (01) : 149 - 155
[10] WILLIAMS LT, 1977, J BIOL CHEM, V252, P2787

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