A RAPID ASSAY OF SURAMIN IN PLASMA

被引：18

作者：

TONG, WP

SCHER, HI

PETRYLAK, DP

DNISTRIAN, A

CURLEY, T

VASQUEZ, J

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT MED,DIV SOLID TUMOR ONCOL,GENITOURINARY ONCOL SERV,NEW YORK,NY 10021

[2] MEM SLOAN KETTERING CANC CTR,DEPT CLIN CHEM,NEW YORK,NY 10021

[3] CORNELL UNIV,MED CTR,COLL MED,DEPT MED,NEW YORK,NY 10021

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 11期

关键词：

D O I：

10.1080/01483919008049030

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The polysulfonated napthylurea suramin is currently undergoing extensive clinical trials. A narrow therapeutic window requires frequent dose adjustment to minimize toxicity. A simple, rapid and reproducible assay was developed for measuring suramin levels in plasma. Plasma samples are injected directly onto the column and eluted isocratically with acetonitrile and an ion pairing reagent. Retention time is approximately two minutes, recovery greater than 95% throughout the range of 50–300 ug/ml, with sensitivities to concentrations of 5 ug. A small sample size (0.5 ul) gave similar results allowing assays of finger-stick samples. Equal accuracy was. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：2269 / 2284

页数：16

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