ULTRASONOGRAPHIC DETECTION OF THE 2ND-TRIMESTER FETUS WITH TRISOMY-18 AND TRISOMY-21

被引：41

作者：

GINSBERG, N ^{[1
]}

CADKIN, A ^{[1
]}

PERGAMENT, E ^{[1
]}

VERLINSKY, Y ^{[1
]}

机构：

[1] ILLINOIS MASON MED CTR,DEPT OBSTET & GYNECOL,REPROD & MED GENET SECT,CHICAGO,IL 60657

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1990年 / 163卷 / 04期

关键词：

fetus; Trisomy; 18; trisomy; 21; ultrasonographic screening;

D O I：

10.1016/0002-9378(90)90686-2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Biparietal diameter/femur length ratio and nuchal thickness were found to be sensitive indicators for the prenatal detection of trisomy 18 and trisomy 21. A biparietal diameter/femur length ratio >1.5 SD above the control mean correctly identified 5 of 11 (46%) fetuses with trisomy 21 and 3 of 4 (75%) fetuses with trisomy 18. Nuchal thickening (6 mm or more) correctly identified 5 of 12 (41%) fetuses with trisomy 21 and 2 of 4 (50%) fetuses with trisomy 18. The sensitivity and specificity of the biparietal diameter/femur length ratio in detecting either aneuploidy was 53% and 93%, respectively, whereas a thickened nuchal fold had a sensitivity of 44% and a specificity of 100%. The combined use of the two ultrasonographic measurements had an overall sensitivity of 81% and a specificity of 93%. Prospective ascertainment of these two trisomies appears warranted in low-risk populations. © 1990.

引用

页码：1186 / 1190

页数：5

共 17 条

[1] DOWNS-SYNDROME - RECENT TRENDS IN THE UNITED-STATES
ADAMS, MM
ERICKSON, JD
LAYDE, PM
OAKLEY, GP
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1981, 246 (07): : 758 - 760
[2] SONOGRAPHIC IDENTIFICATION OF 2ND-TRIMESTER FETUSES WITH DOWNS-SYNDROME
BENACERRAF, BR
GELMAN, R
FRIGOLETTO, FD
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (22) : 1371 - 1376
[3] BENACERRAF BR, 1987, RADIOLOGY, V163, P81
[4] ABNORMAL MATERNAL SERUM CHORIONIC-GONADOTROPIN LEVELS IN PREGNANCIES WITH FETAL CHROMOSOME-ABNORMALITIES
BOGART, MH
PANDIAN, MR
JONES, OW
[J]. PRENATAL DIAGNOSIS, 1987, 7 (09) : 623 - 630
[5] LOW 2ND TRIMESTER MATERNAL SERUM UNCONJUGATED ESTRIOL IN PREGNANCIES WITH DOWNS-SYNDROME
CANICK, JA
KNIGHT, GJ
PALOMAKI, GE
HADDOW, JE
CUCKLE, HS
WALD, NJ
[J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1988, 95 (04): : 330 - 333
[6] CUCKLE HS, 1984, LANCET, V1, P926
[7] ELIAS S, 1987, NEW ENGL J MED, V317, P1409
[8] HOOK EB, 1983, AM J HUM GENET, V35, P110
[9] CHROMOSOMAL ABNORMALITY RATES AT AMNIOCENTESIS AND IN LIVE-BORN INFANTS
HOOK, EB
CROSS, PK
SCHREINEMACHERS, DM
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1983, 249 (15): : 2034 - 2038
[10] JEANTY P, 1984, J ULTRAS MED, V3, P75

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