ALTERATIONS IN GENE-EXPRESSION AFTER CHRONIC TREATMENT OF GLIOMA-CELLS IN CULTURE WITH METHYLMERCURIC CHLORIDE

被引：15

作者：

RAMANUJAM, M ^{[1
]}

PRASAD, KN ^{[1
]}

机构：

[1] UNIV COLORADO, DEPT RADIOL, DENVER, CO 80262 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 19期

关键词：

D O I：

10.1016/0006-2952(79)90597-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cellular and molecular mechanisms of methylmercuric chloride (CH3HgCl)-induced damage to the nerve tissue were studied in a monolayer culture of glioma cells (C-6). Chronic treatment of glioma cells with low concentrations (0.05-0.1 μM) of CH3HgCl produced a significant alteration in gene expression, as evidenced by changes in the amounts and net phsophorylation profiles of specific proteins. However, the morphology and doubling time did not change. © 1979.

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页码：2979 / 2984

页数：6

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