MECHANISMS OF GAS-EXCHANGE WITH DIFFERENT GASES DURING CONSTANT-FLOW VENTILATION

被引:3
作者
CHEN, FJ
MENON, AS
LICHTENSTEIN, SV
ZAMEL, N
SLUTSKY, AS
机构
[1] UNIV TORONTO,MT SINAI HOSP,DEPT MED & SURG,TORONTO M5G 1X5,ONTARIO,CANADA
[2] ST MICHAELS HOSP,TORONTO M5B 1W8,ONTARIO,CANADA
关键词
cardiogenic oscillations; turbulent jet;
D O I
10.1152/jappl.1990.68.1.88
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To investigate the mechanisms responsible for the difference in gas exchange during constant-flow ventilation (CFV) when using gases with different physical properties, we used mixtures of 70% N2-30% O2 (N2-O2) and 70% He-30% O2 (He-O2) as the insufflating gases in 12 dogs. All dogs but one had higher arterial PCO2 (Pa(CO2)) with He-O2 compared with N2-O2. At a flow of 0.37 ± 0.12 l/s, the mean Pa(CO2)'s with N2-O2 and He-O2 were 41.3 ± 13.9 and 53.7 ± 20.3 Torr, respectively (P<0.01); at a flow rate of 0.84 ± 0.17 l/s, the mean Pa(CO2) 's were 29.1 ± 11.3 and 35.3 ± 13.6 Torr, respectively (P<0.01). The chest was then opened to alter the apposition between heart and the lungs, thereby reducing the extent of cardiogenic oscillations by 58.4 ± 18.4%. This intervention did not significantly alter the difference in Pa(CO2) between N2-O2 and He-O2 from that observed in the intact animals, although the individual Pa(CO2) values for each gas mixture did increase. When the Pa(CO2) was plotted against stagnation pressure (ρV̇2), the difference in Pa(CO2) between N2-O2 and He-O2 was nearly abolished in both the closed- and open-chest animals. These findings suggest that the different Pa(CO2)'s obtained by insufflating gases with different physical properties at a fixed flow rate, catheter position, and lung volume result mainly from a difference in the properties of the jet.
引用
收藏
页码:88 / 93
页数:6
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