VARIABLE (DG-DT)N.(DC-DA)N SEQUENCES IN THE PORCINE GENOME

被引：104

作者：

WINTERO, AK ^{[1
]}

FREDHOLM, M ^{[1
]}

THOMSEN, PD ^{[1
]}

机构：

[1] ROYAL VET & AGR UNIV,DEPT ANIM PROD & ANIM HLTH,DIV ANIM GENET,BULOWSVEJ 13,DK-1870 FREDERIKSBERG C,DENMARK

来源：

GENOMICS | 1992年 / 12卷 / 02期

关键词：

D O I：

10.1016/0888-7543(92)90375-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

One of the more widely studied simple repeat sequences in the mammalian genome is the (dG-dT)n·(dC-dA)n dinucleotide repeat sequence. As these repeats are highly polymorphic and fairly evenly distributed in diverse mammalian genomes, they constitute a very powerful tool for genetic mapping in a wide variety of species. So far, the knowledge about repeat sequences in the porcine genome is sparse and only a few areas of this genome have been sequenced. We have isolated and characterized 108 porcine (dG-dT)n·(dC-dA)n sequences and studied the distribution of these, both by investigating random clones and by performing in situ hybridization. A remarkable correlation between humans and pigs was found with respect to the structure, to the number of repeat blocks, and to the chromosomal distribution. © 1992.

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页码：281 / 288

页数：8

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