TRANSACTIVATION OF THE TUMOR-NECROSIS-FACTOR-ALPHA PROMOTER BY THE HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I TAX1 PROTEIN

被引：43

作者：

ALBRECHT, H

SHAKHOV, AN

JONGENEEL, CV

机构：

[1] LUDWIG INST CANC RES,LAUSANNE BRANCH,CH-1066 EPALINGES,SWITZERLAND

[2] SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 10期

关键词：

D O I：

10.1128/JVI.66.10.6191-6193.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a cotransfection assay, the human T-cell leukemia virus type I Tax1 gene product specifically activated transcription from the mouse tumor necrosis factor alpha-promoter. The activation patterns of 5' deletion mutants, artificial enhancer constructs, and point mutations in the promoter indicate that the major Tax1-responsive element is a site at position -655 which binds the NF-kappa-B/rel and NF-GMa transcription factors.

引用

页码：6191 / 6193

页数：3

共 25 条

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