THE SYNTHESIS OF 11-CYCLOPROPYL-5,11-DIHYDRO-4-(HYDROXYMETHYL)-6H-DIPYRIDO[3,2-B-2',3'-E][1,4]DIAZEPIN-6-ONE, A PUTATIVE METABOLITE OF THE HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR NEVIRAPINE

被引：9

作者：

PATEL, UR ^{[1
]}

PROUDFOOT, JR ^{[1
]}

机构：

[1] BOEHRINGER INGELHEIM PHARMACEUT INC,DEPT MED CHEM,900 RIDGEBURY RD,POB 368,RIDGEFIELD,CT 06877

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 14期

关键词：

D O I：

10.1021/jo00040a055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[No abstract available]

引用

页码：4023 / 4025

页数：3

共 11 条

[1]

BRANDSMA L, 1990, PREPARATIVE POLAR OR, V2, P136

[2]

COHEN KA, 1991, J BIOL CHEM, V266, P14670

[3]

COLVIN EW, 1988, SILICON REAGENTS ORG, P60

[4] OXIDATIVE CONVERSIONS OF SULFENE CYCLOADDUCTS FROM AZAHEPTAFULVENES AND FROM TROPONE TO 1,2-DISUBSTITUTED INDOLES AND 2-ARYLBENZOFURANS, RESPECTIVELY [J].

DEAN, BD ;

TRUCE, WE .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (17) :3575-3576

[5] ORGANOSILICON COMPOUNDS .18. THE INTERACTION OF (ARYLDIMETHYLSILYL)METHYL CHLORIDES AND SODIUM ETHOXIDE IN ETHANOL [J].

EABORN, C ;

JEFFREY, JC .

JOURNAL OF THE CHEMICAL SOCIETY, 1957, (JAN) :137-144

[6] A ONE-POT CONVERSION OF THE PHENYLDIMETHYLSILYL GROUP INTO A HYDROXYL GROUP [J].

FLEMING, I ;

SANDERSON, PEJ .

TETRAHEDRON LETTERS, 1987, 28 (36) :4229-4232

[7] THE PHENYLDIMETHYLSILYL GROUP AS A MASKED FORM OF THE HYDROXY GROUP [J].

FLEMING, I ;

HENNING, R ;

PLAUT, H .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (01) :29-31

[8] NOVEL NONNUCLEOSIDE INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE .1. TRICYCLIC PYRIDOBENZODIAZEPINONES AND DIPYRIDODIAZEPINONES [J].

HARGRAVE, KD ;

PROUDFOOT, JR ;

GROZINGER, KG ;

CULLEN, E ;

KAPADIA, SR ;

PATEL, UR ;

FUCHS, VU ;

MAULDIN, SC ;

VITOUS, J ;

BEHNKE, ML ;

KLUNDER, JM ;

PAL, K ;

SKILES, JW ;

MCNEIL, DW ;

ROSE, JM ;

CHOW, GC ;

SKOOG, MT ;

WU, JC ;

SCHMIDT, G ;

ENGEL, WW ;

EBERLEIN, WG ;

SABOE, TD ;

CAMPBELL, SJ ;

ROSENTHAL, AS ;

ADAMS, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (07) :2231-2241

[9] INHIBITION OF HIV-1 REPLICATION BY A NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR [J].

MERLUZZI, VJ ;

HARGRAVE, KD ;

LABADIA, M ;

GROZINGER, K ;

SKOOG, M ;

WU, JC ;

SHIH, CK ;

ECKNER, K ;

HATTOX, S ;

ADAMS, J ;

ROSEHTHAL, AS ;

FAANES, R ;

ECKNER, RJ ;

KOUP, RA ;

SULLIVAN, JL .

SCIENCE, 1990, 250 (4986) :1411-1413

[10] (DIISOPROPOXYMETHYLSILYL)METHYL GRIGNARD-REAGENT - A NEW, PRACTICALLY USEFUL NUCLEOPHILIC HYDROXYMETHYLATING AGENT [J].

TAMAO, K ;

ISHIDA, N ;

KUMADA, M .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (12) :2120-2122

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