EVIDENCE FOR THE LOCALIZATION OF HEMOPEXIN IMMUNOREACTIVITY IN NEURONS IN THE HUMAN BRAIN

被引：45

作者：

MORRIS, CM

CANDY, JM

EDWARDSON, JA

BLOXHAM, CA

SMITH, A

机构：

[1] NEWCASTLE GEN HOSP,DEPT PATHOL,NEWCASTLE TYNE NE4 6BE,TYNE & WEAR,ENGLAND

[2] UNIV MISSOURI,SCH BIOL SCI,DIV MOLEC BIOL & BIOCHEM,KANSAS CITY,MO 64110

来源：

NEUROSCIENCE LETTERS | 1993年 / 149卷 / 02期

关键词：

HEMOPEXIN; HEME; IRON; TRANSFERRIN; HUMAN BRAIN; IMMUNOCYTOCHEMISTRY;

D O I：

10.1016/0304-3940(93)90756-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Haemopexin is a 60 kDa serum glycoprotein responsible for the transport of haem to tissues such as liver, by receptor-mediated endocytosis, in an analogous manner to the iron transport protein transferrin, with recycling of intact haemopexin. The immunocytochemical distribution of haemopexin has been investigated, using a monospecific polyclonal antiserum to human haemopexin, in human brain. Neurones in all the brain regions studied showed immunostaining of the soma, axons and dendrites. A few scattered glial cells exhibited positive immunostaining. Oligodendrocytes and choroid plexus epithelial cells lacked haemopexin immunoreactivity. Thus, haemopexin is present within neurones and we propose that this protein may play an important role in haem transport for neuronal iron homeostasis.

引用

页码：141 / 144

页数：4

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