STUDIES ON THE EPIDEMIOLOGY OF CHILD INFECTIONS IN THE BARI AREA (SOUTH ITALY) .7. EPIDEMIOLOGY OF EPSTEIN-BARR-VIRUS INFECTIONS

被引：15

作者：

LEOGRANDE, G

JIRILLO, E

机构：

[1] Istituto di Microbiologia Medica - Cattedra di Immunologia, Facoltà di Medicina dell'Università di Bari, Bari, 70124, Piazza Giulio Cesare

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1993年 / 9卷 / 04期

关键词：

EPSTEIN-BARR VIRUS; SEROEPIDEMIOLOGY;

D O I：

10.1007/BF00157392

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Serological patterns against Epstein-Barr virus (EBV) specific antigens were determined in 3732 healthy babies and children aged 0-10 years living in the Bari area (South Italy). IgG antibodies against EBV capsid antigen (VCA) were found in 2713 subjects (72.7%). Seropositivity rates, high in the first semester of life (83.8%), declined between 6 and 12 months (65.6%) and even further between 1 and 2 years (43.8%). After 2 years the frequency of positive children rose progressively reaching steady levels between 5 and 7 years (80.2%) and between 8 and 10 years (81.9%). IgA antibodies against VCA, IgG anti-early viral antigen (EA) and IgG against virus-associated nuclear antigens (EBNA) were found in 17.9%, 15.9% and 25.7% of the subjects tested, respectively. IgM anti-VCA were found only in 35 (0.9%) children, but 818 (21.9%) exhibited antibody patterns suggestive of a recent infection: IgG anti-VCA > 1:160 alone or in association with IgA anti-VCA or IgG anti-EA or both. These results suggest that in this area the primary infection by EBV occur early in life, with immunity to EBV acquired primarily after 4 years.

引用

页码：368 / 372

页数：5

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