LIGHT-MICROSCOPIC AND ELECTRON-MICROSCOPIC LOCALIZATION OF THE GLUTAMATE-RECEPTOR CHANNEL DELTA-2 SUBUNIT IN THE MOUSE PURKINJE-CELL

被引：68

作者：

TAKAYAMA, C ^{[1
]}

NAKAGAWA, S ^{[1
]}

WATANABE, M ^{[1
]}

MISHINA, M ^{[1
]}

INOUE, Y ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT PHARMACOL,TOKYO 113,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 188卷 / 02期

关键词：

GLUTAMATE RECEPTOR CHANNEL DELTA-2 SUBUNIT; IMMUNOHISTOCHEMISTRY; CEREBELLAR PURKINJE CELL; PARALLEL FIBER; DENDRITIC SPINE; ECTOPIC PURKINJE CELL;

D O I：

10.1016/0304-3940(95)11403-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization of the glutamate receptor channel delta 2 subunit was investigated by immunohistochemistry. The delta 2-immunoreactivity was observed exclusively in the molecular layer of the cerebellar cortex. The electron microscopic analysis showed that the delta 2 subunit was localized in the dendritic spines of the Purkinje cells. The immunopositive spines often formed synaptic contacts with parallel fiber varicosities. As for the Purkinje cells ectopically localized in the cerebellar nuclei and brain stem, the dendritic shafts and cell bodies were strongly labeled. These ectopic Purkinje cells also formed asymmetrical synapses at the delta 2-immunopositive dendritic spines. Considering the specific localization of the delta 2 subunit in the postsynaptic site of the Purkinje cells, the subunit is suggested to be involved in the excitatory synaptic transmission in the cells, as a component of the glutamate receptor channel.

引用

页码：89 / 92

页数：4

共 15 条

[1] SELECTIVE EXPRESSION OF THE GLUTAMATE-RECEPTOR CHANNEL DELTA-2 SUBUNIT IN CEREBELLAR PURKINJE-CELLS [J].