A DOUBLE-BLIND-STUDY TO ASSESS THE PRIMARY IRRITANCY OF FLURBIPROFEN (LOCAL-ACTION TRANSCUTANEOUS) WHEN APPLIED TO THE SKIN OF CAUCASIANS

A single-centre, double-blind, single-dose study was conducted to assess the primary irritancy of a local action transcutaneous (LAT) patch preparation of flurbiprofen (Targus/TransAct LAT) when applied to the skin of 24 Caucasian volunteers. Comparisons were made of flurbiprofen LAT with non-medicated control, unperfumed moisture cream and a plain lint patch. It was found that the primary irritancy of the flurbiprofen LAT preparation was minimal. This finding, together with previous experience in Japanese subjects, suggests that skin irritancy is unlikely to be a prevalent adverse event when flurbiprofen LAT is used clinically in Caucasian patients.