CEREBRAL OXYGEN UTILIZATION ANALYZED BY THE USE OF O-17 AND ITS NUCLEAR-MAGNETIC-RESONANCE

被引：47

作者：

ARAI, T

NAKAO, SI

MORI, K

ISHIMORI, K

MORISHIMA, I

MIYAZAWA, T

FRITZZIEROTH, B

机构：

[1] KYUSHU UNIV,GRAD SCH ENGN,DIV MOLEC ENGN,FUKUOKA 812,JAPAN

[2] NIHON SCHERING KK,RES DEPT,OSAKA,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91447-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to assess the usefulness of oxygen-17, a stable isotope of oxygen, oxygen-17, was administered to rats for studying cerebral oxygen utilization, and the produced metabolic water was detected by 17O-NMR spectroscopy in vitro and an 1H-NMR imaging system in vivo. In the vitro study, the increment in signal amplitude of oxygen-17 was observed in the brain extracted from rats that inhaled oxygen-17 gas. The in vivo study demonstrated that there were changes in the 1H-NMR image intensity of brain of rats that inhaled oxygen-17 gas. These facts indicate that oxygen-17 can serve as a tracer in the study of cerebral oxygen utilization. © 1990.

引用

页码：153 / 158

页数：6

共 8 条

[1]

ALBERTS B, 1989, MOL BIOL CELL, P350

[2] METHOD FOR THE DETECTION OF TISSUE METABOLITE (H-2 O-17) IN BRAIN BY PROTON MAGNETIC-RESONANCE IMAGING [J].