INHIBITION OF PROSTACYCLIN-LIKE MATERIAL FORMATION BY CADMIUM

被引：11

作者：

CAPRINO, L

TOGNA, G

机构：

[1] Istituto di Farmacologia Cattedra, Tossicologia Università Cattolica del Sacro Cuore Rome

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1979年 / 48卷 / 03期

关键词：

D O I：

10.1016/0041-008X(79)90435-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The activity of cadmium on the platelet and vascular wall prostaglandin system was studied. This metal was found to inhibit the production of prostacyclin (PGI2) by vascular wall tissue, without affecting the platelet aggregation induced by arachidonic acid or ADP. In view of the vasodilator activity of PGI2 these data suggest an hypothesis on the origin of cadmium-induced hypertension and on the development of vascular thrombi. © 1979.

引用

页码：529 / 531

页数：3

共 9 条

[1]

BERRY JP, 1972, PATHOL BIOL, V20, P401

[2] AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL [J].