The enzymatic synthesis and ant HIV-1 activity of 9-beta-D-2 ',3 '-dideoxynucleosides of N(6)-substituted purines

被引：6

作者：

Betbeder, D. ^{[1
]}

Hutchinson, D. W. ^{[1
]}

Richards, A. O'L ^{[1
]}

Mahood, N. ^{[2
]}

Kinchington, D. ^{[3
]}

机构：

[1] Warwick Univ, Chem Dept, Coventry CV4 7AL, W Midlands, England

[2] Med Res Council Collaborat Ctr, London NW7 1AD, England

[3] St Marys Hosp, Med Sch, Dept Med Microbiol, Div Virol, London WC2 1PG, England

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1990年 / 1卷 / 04期

关键词：

D O I：

10.1177/095632029000100404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

9-beta-D-2',3'-dideoxyribonucleosides of four N(6)-substituted purines and 1-deazapurine were prepared using crude nucleoside N-deoxyribosyltransferases (EC 2.4.2.6) from Lactobacillus leichmannii. The 2',3'-dideoxynucleosides derived from N(6)-substituted purines (1-4) are inhibitors of the replication of human immunodeficiency virus type 1 (HIV-1), with EC90 values in the range 20-100 and 20-200 mu m, depending on the cell line used, and have low in vitro toxicity at their effective concentrations.

引用

页码：249 / 253

页数：5

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