BOVINE L-SELECTIN - A PERIPHERAL LYMPHOCYTE HOMING RECEPTOR

被引：18

作者：

BOSWORTH, BT

DOWBENKO, D

SHUSTER, DE

HARP, JA

机构：

[1] USDA ARS,NATL ANIM DIS CTR,METAB DIS & IMMUNOL RES UNIT,POB 70,AMES,IA 50010

[2] GENENTECH INC,DEPT IMMUNOBIOL,S SAN FRANCISCO,CA 94080

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1993年 / 37卷 / 3-4期

关键词：

D O I：

10.1016/0165-2427(93)90194-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cDNA clone encoding for the bovine peripheral lymph node homing receptor (L-selectin) was isolated and sequenced. The predicted amino acid sequence of bovine L-selectin showed an overall high identity with that of human and murine L-selectin. However, the cytoplasmic tail of bovine L-selectin showed little similarity to that of human and murine L-selectin. The monoclonal antibody DREG-56, which recognizes human L-selectin, blocked the binding of bovine peripheral blood lymphocytes to high-walled endothelial venules in murine peripheral lymph nodes. Surface expression of bovine L-selectin was high in lymphocytes isolated from peripheral lymph nodes and low in lymphocytes isolated from Peyer's patches. This evidence strongly suggests that bovine L-selectin is a peripheral lymphocyte homing receptor.

引用

页码：201 / 215

页数：15

共 40 条

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