REGULATION OF THE TRANSCRIPTION FACTOR C-JUN BY NERVE GROWTH-FACTOR IN ADULT SENSORY NEURONS

被引：74

作者：

GOLD, BG ^{[1
]}

STORMDICKERSON, T ^{[1
]}

AUSTIN, DR ^{[1
]}

机构：

[1] OREGON HLTH SCI UNIV,DEPT CELL BIOL & ANAT,PORTLAND,OR 97201

来源：

NEUROSCIENCE LETTERS | 1993年 / 154卷 / 1-2期

关键词：

AXON REACTION; AXOTOMY; DORSAL ROOT GANGLION; IMMEDIATE-EARLY GENE; NERVE GROWTH FACTOR; NGF ANTISERUM; OSMOTIC MINIPUMP; PROTOONCOGENE;

D O I：

10.1016/0304-3940(93)90188-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the regulation by nerve growth factor (NGF) of the immediate-early gene (proto-oncogene) c-jun in adult dorsal root ganglion (DRG) neurons using immunocytochemistry to c-JUN (the protein product of the proto-oncogene c-jun). Following a sciatic nerve crush, the injury-induced increase in c-JUN-like immunostaining was reduced in DRG neurons by continuous intrathecal infusion of NGF for one week. Conversely, in intact DRG neurons (i.e., without Wallerian degeneration), c-JUN-like immunoreactivity was markedly increased following four weeks of daily NGF antiserum injections (to remove target tissue-derived NGF) into the hindfoot. Taken together, these findings indicate that nerve transection (axotomy) results in a loss of target tissue-derived NGF leading to induction of the transcription factor c-jun which may play a role in axonal regeneration.

引用

页码：129 / 133

页数：5

共 25 条

[1] NERVE GROWTH-FACTOR PREVENTS TOXIC NEUROPATHY IN MICE [J].

APFEL, SC ;

LIPTON, RB ;

AREZZO, JC ;

KESSLER, JA .

ANNALS OF NEUROLOGY, 1991, 29 (01) :87-90

[2] NERVE GROWTH-FACTOR PREVENTS EXPERIMENTAL CISPLATIN NEUROPATHY [J].

APFEL, SC ;

AREZZO, JC ;

LIPSON, L ;

KESSLER, JA .

ANNALS OF NEUROLOGY, 1992, 31 (01) :76-80

[3] GROWTH-FACTOR SIGNALING - WHERE IS THE SPECIFICITY [J].

CHAO, MV .

CELL, 1992, 68 (06) :995-997

[4]

GOLD B G, 1991, Society for Neuroscience Abstracts, V17, P1497

[5]

GOLD BG, 1991, J NEUROSCI, V11, P943

[6] THE TRANSCRIPTION FACTORS C-JUN, JUN D AND CREB, BUT NOT FOS AND KROX-24, ARE DIFFERENTIALLY REGULATED IN AXOTOMIZED NEURONS FOLLOWING TRANSECTION OF RAT SCIATIC-NERVE [J].

HERDEGEN, T ;

FIALLOSESTRADA, CE ;

SCHMID, W ;

BRAVO, R ;

ZIMMERMANN, M .

MOLECULAR BRAIN RESEARCH, 1992, 14 (03) :155-165

[7] NEUROFILAMENT AND TUBULIN EXPRESSION RECAPITULATES THE DEVELOPMENTAL PROGRAM DURING AXONAL REGENERATION - INDUCTION OF A SPECIFIC BETA-TUBULIN ISOTYPE [J].

HOFFMAN, PN ;

CLEVELAND, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4530-4533

[8] INDUCTION OF C-FOS-LIKE PROTEIN IN SPINAL-CORD NEURONS FOLLOWING SENSORY STIMULATION [J].

HUNT, SP ;

PINI, A ;

EVAN, G .

NATURE, 1987, 328 (6131) :632-634

[9] LONG-TERM INCREASE IN THE LEVELS OF C-JUN MESSENGER-RNA AND JUN PROTEIN-LIKE IMMUNOREACTIVITY IN MOTOR AND SENSORY NEURONS FOLLOWING AXON DAMAGE [J].

JENKINS, R ;

HUNT, SP .

NEUROSCIENCE LETTERS, 1991, 129 (01) :107-110

[10] HUMAN NERVE GROWTH-FACTOR PREVENTS DEGENERATION OF BASAL FOREBRAIN CHOLINERGIC NEURONS IN PRIMATES [J].

KOLIATSOS, VE ;

CLATTERBUCK, RE ;

NAUTA, HJW ;

KNUSEL, B ;

BURTON, LE ;

HEFTI, FF ;

MOBLEY, WC ;

PRICE, DL .

ANNALS OF NEUROLOGY, 1991, 30 (06) :831-840

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