PREPARATION OF OLIGODEOXYNUCLEOTIDES CONTAINING 6-METHYLTHIOPURINE RESIDUES BY CHEMICAL SYNTHESIS OR SPECIFIC METHYLATION

被引：15

作者：

XU, YZ

ZHENG, QG

SWANN, PF

机构：

[1] Cancer Research Campaign, Nitrosamine-Induced Cancer Research Group, Department of Biochemistry and Molecular Biology, University College London, London WC1E6BT, Gower Street

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012504

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two methods (chemical synthesis and specific methylation) are described for the preparation of oligodeoxynucleotides containing 6-methylthiopurine residues. 6-Methylthiopurine phosphoramidite (6) is prepared and incorporated into oligomers. Methylation with methyl iodide of 6-thiopurine (or 6-thioguanine) in oligonucleotides also leads to exclusive production of 6-methylthiopurine (or 6-methylthioguanine) oligomers.

引用

页码：929 / 933

页数：5

共 10 条

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