BI-MODAL EFFECT OF PIPERONYL BUTOXIDE ON O- AND P-HYDROXYLATIONS OF BIPHENYL BY MOUSE MICROSOMES

被引：34

作者：

JAFFE, H

FUJII, K

GUERIN, H

SENGUPTA, M

EPSTEIN, SS

机构：

[1] Laboratories of Environmental Toxicology and Carcinogenesis, Children's Cancer Research Foundation, Inc.

[2] Department of Pathology, Harvard Medical School, Boston, MA

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-2952(69)90108-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Piperonyl butoxide, immediately after intraperitoneal injection into adult male Swiss mice, produces a bi-modal effect of a transient stimulation of o-hydroxylation and a concomitant suppression of p-hydroxylation of biphenyl by their liver microsomes. Based on the initial kinetic relationship between these two activities and the characterization of their respective responses to varying dosages of piperonyl butoxide, it is shown that this bi-modal effect is due to a shift in equilibrium between the two microsomal enzyme activities, presumably through an isozymic transformation. © 1969.

引用

页码：1045 / +

页数：1

共 26 条

[1] EFFECT OF PYRETHRIN SYNERGISTS ESPECIALLY SESAMEX ON INSECTICIDAL POTENCY OF HEXACHLOROCYCLOPENTADIENE DERIVATIVES ( CYCLODIENE INSECTICIDES ) IN ADULT HOUSEFLY MUSCA DOMESTICA L [J].