HIV-1 REPRODUCTION IS INHIBITED BY PEPTIDES DERIVED FROM THE N-TERMINI AND C-TERMINI OF HIV-1 PROTEASE

被引：66

作者：

SCHRAMM, HJ

NAKASHIMA, H

SCHRAMM, W

WAKAYAMA, H

YAMAMOTO, N

机构：

[1] TOKYO MED & DENT UNIV,SCH MED,TOKYO 113,JAPAN

[2] UNIV MUNICH,HAMOSTASEOL ABT,W-8000 MUNICH 2,GERMANY

[3] YAMAGUCHI UNIV,SCH MED,DEPT VIROL & PARASITOL,YAMAGUCHI 753,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91895-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two octapeptides derived from the sequence of the N- and C-termini of HIV-1 protease were tested for their ability to inhibit HIV-1 reproduction. Weak inhibitory activity was found with each of the two peptides. It is assumed that HIV-1 protease is the target of the inhibitory action. In spite of the moderate inhibitory activity the results are encouraging since they may be improved by various means. © 1991.

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页码：847 / 851

页数：5

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