TONE-INDUCED STEREOCILIA LESIONS AS A FUNCTION OF EXPOSURE LEVEL AND DURATION IN THE HAMSTER COCHLEA

被引:19
作者
KALTENBACH, JA [1 ]
SCHMIDT, RN [1 ]
KAPLAN, CR [1 ]
机构
[1] WAYNE STATE UNIV,SCH MED,DEPT OTOLARYNGOL,DETROIT,MI 48201
关键词
COCHLEA; STEREOCILIA; NOISE-INDUCED HEARING LOSS; ACOUSTIC TRAUMA; HAMSTER;
D O I
10.1016/0378-5955(92)90022-F
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
The present study presents an atlas of the effects of 10 kHz tone exposures of different levels and durations on cochlear hair cells and their stereocilia in the Syrian golden hamster. Animals were sound exposed while under anesthesia. The exposure conditions were varied over an intensity range of 90-129 dB SPL; at the highest levels (126-129 dB SPL) the exposure periods were varied over a range of 30 min to 4 h. In animals with mild damage the lesions were commonly restricted to either the inner hair cells and/or the first row of outer hair cells; the order of damage susceptibility was IHC, OHC1, OHC2, OHC3. Damage to the second and third rows of outer hair cells were found only in animals with the severest lesions. Possible mechanisms underlying the row-specific distributions of these lesions and relative susceptibilities of the 4 rows of hair cells are discussed.
引用
收藏
页码:205 / 215
页数:11
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