ORAL SUSTAINED-RELEASE DRUG DELIVERY SYSTEMS USING POLYCARBONATE MICROSPHERES CAPABLE OF FLOATING ON THE GASTRIC FLUID

被引：72

作者：

THANOO, BC ^{[1
]}

SUNNY, MC ^{[1
]}

JAYAKRISHNAN, A ^{[1
]}

机构：

[1] SREE CHITRA TIRUNAL INST MED SCI & TECHNOL,DIV POLYMER CHEM,BIOMED TECHNOL WING,TRIVANDRUM 695012,INDIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1993.tb03672.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polycarbonate microspheres loaded with aspirin, griseofulvin and p-nitroaniline were prepared by a solvent evaporation technique. High drug loading (> 50%) was achieved by this process. Drug-loaded microspheres were found to float on simulated gastric fluid and intestinal fluid. Drug-release studies were carried out in these fluids at 37-degrees-C. Increasing the drug to polymer ratio in the microspheres increased both their mean particle size and the release rate of the drugs. It was concluded that sustained delivery of drugs could be effected using this matrix.

引用

页码：21 / 24

页数：4

共 8 条

[1]

BOLTON S, 1989, Patent No. 297978

[2]

HOON JR, 1974, JAMA-J AM MED ASSOC, V299, P841

[3] PHYSICOCHEMICAL BASIS OF THE BUFFERED ACETYLSALICYLIC ACID CONTROVERSY [J].

LEVY, G ;

HAYES, BA .

NEW ENGLAND JOURNAL OF MEDICINE, 1960, 262 (21) :1053-1058

[4]

Mitra SB., 1984, POLYM BIOMATERIALS, P293

[5]

Tossounian S., 1989, U.S. patent, Patent No. [4,814,179, 4814179]

[6]

VOGEL AI, 1978, TXB PRACTICAL ORGANI, P831

[7]

WATANABE S, 1975, Patent No. 2510620

[8]

[No title captured], Patent No. 4126672

← 1 →