MONOCLONAL-ANTIBODIES DIRECTED AGAINST T-CELL EPITOPES PRESENTED BY CLASS-I MHC ANTIGENS

被引：26

作者：

DUC, HT ^{[1
]}

RUCAY, P ^{[1
]}

RIGHENZI, S ^{[1
]}

HALLEPANNENKO, O ^{[1
]}

KOURILSKY, P ^{[1
]}

机构：

[1] INST PASTEUR, UNITE BIOL MOLEC GENE, INSERM, U277, F-75724 PARIS 15, FRANCE

来源：

INTERNATIONAL IMMUNOLOGY | 1993年 / 5卷 / 04期

关键词：

CLASS-I MHC ANTIGENS; T-CELL EPITOPES;

D O I：

10.1093/intimm/5.4.427

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies which recognize a synthetic peptide derived from influenza virus nucleoprotein in association with a murine class I MHC molecule (K(d)) have been isolated. One such antibody has been characterized and shown to react neither with the peptide nor with the K(d) molecule, but only with the K(d) - peptide complex. Evidence is given that it recognizes the naturally processed peptide located in the peptide binding groove, i.e. the antigenic moiety presented to T cells.

引用

页码：427 / 431

页数：5

共 26 条

[1] A MONOCLONAL-ANTIBODY RECOGNIZES A SUBSET OF THE H-2DD MOUSE MAJOR CLASS-I ANTIGENS [J].

ABASTADO, JP ;

DARCHE, S ;

JOUIN, H ;

DELARBRE, C ;

GACHELIN, G ;

KOURILSKY, P .

RESEARCH IN IMMUNOLOGY, 1989, 140 (5-6) :581-594

[2] IMMUNOMODULATION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY ANTIBODIES TO THE ANTIGEN-IA COMPLEX [J].

AHARONI, R ;

TEITELBAUM, D ;

ARNON, R ;

PURI, J .

NATURE, 1991, 351 (6322) :147-150

[3] ALLOREACTIVE CYTOLYTIC T-CELL CLONES PREFERENTIALLY RECOGNIZE CONFORMATIONAL DETERMINANTS ON HISTOCOMPATIBILITY ANTIGENS - ANALYSIS WITH GENETICALLY ENGINEERED HYBRID ANTIGENS [J].

ARNOLD, B ;

HORSTMANN, U ;

KUON, W ;

BURGERT, HG ;

HAMMERLING, GJ ;

KVIST, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7030-7034

[4] ENHANCED RECOGNITION OF A MODIFIED PEPTIDE ANTIGEN BY CYTOTOXIC-T CELLS SPECIFIC FOR INFLUENZA NUCLEOPROTEIN [J].

BODMER, HC ;

PEMBERTON, RM ;

ROTHBARD, JB ;

ASKONAS, BA .

CELL, 1988, 52 (02) :253-258

[5] CLASS-I-RESTRICTED PROCESSING AND PRESENTATION OF EXOGENOUS CELL-ASSOCIATED ANTIGEN INVIVO [J].

CARBONE, FR ;

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (02) :377-387

[6] GENERATION OF CYTOTOXIC T LYMPHOCYTES INVITRO .1. RESPONSE OF NORMAL AND IMMUNE MOUSE SPLEEN-CELLS IN MIXED LEUKOCYTE-CULTURES [J].

CEROTTINI, JC ;

ENGERS, HD ;

MACDONALD, HR ;

BRUNNER, KT .

JOURNAL OF EXPERIMENTAL MEDICINE, 1974, 140 (03) :703-717

[7]

DUC HT, 1992, CR ACAD SCI III-VIE, V314, P437

[8] IMMUNIZATION WITH SV40-TRANSFORMED CELLS YIELDS MAINLY MHC-RESTRICTED MONOCLONAL-ANTIBODIES [J].

FROSCHER, BG ;

KLINMAN, NR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (01) :196-210

[9] CONTINUOUS CULTURES OF FUSED CELLS SECRETING ANTIBODY OF PREDEFINED SPECIFICITY [J].

KOHLER, G ;

MILSTEIN, C .

NATURE, 1975, 256 (5517) :495-497

[10] COMPETITOR ANALOGS FOR DEFINED T-CELL ANTIGENS - PEPTIDES INCORPORATING A PUTATIVE BINDING MOTIF AND POLYPROLINE OR POLYGLYCINE SPACERS [J].

MARYANSKI, JL ;

VERDINI, AS ;

WEBER, PC ;

SALEMME, FR ;

CORRADIN, G .

CELL, 1990, 60 (01) :63-72

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