STIMULATION OF NERVE GROWTH-FACTOR RECEPTORS IN PC12 BY ACETYL-L-CARNITINE

被引：34

作者：

TAGLIALATELA, G

ANGELUCCI, L

RAMACCI, MT

WERRBACHPEREZ, K

JACKSON, GR

PEREZPOLO, JR

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT HUMAN BIOL CHEM & GENET,436 GAIL BORDEN BLDG F-52,GALVESTON,TX 77550

[2] UNIV ROME LA SAPIENZA,DEPT PHARMACOL,I-00185 ROME,ITALY

[3] INST RES SENESCENCE,I-00040 POMEZIA,ITALY

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 03期

关键词：

D O I：

10.1016/0006-2952(92)90452-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acetyl-L-carnitine (ALCAR) prevents some deficits associated with aging in the central nervous system (CNS), such as the aged-related reduction of nerve growth factor (NGF) binding. The aim of this study was to ascertain whether ALCAR could affect the expression of an NGF receptor (p75NGFR) . Treatment of PC12 cells with ALCAR increased equilibrium binding of I-121-NGF. ALCAR treatment also increased the amount of immunoprecipitable p75NGFR from PC12 cells. Lastly, the level of p75NGFR messenger RNA (mRNA) in PC12 was increased following ALCAR treatment. These results are in agreement with the hypothesis that there is a direct action of ALCAR on p75NGFR expression in aged rodent CNS.

引用

页码：577 / 585

页数：9

共 62 条

[1] NERVE GROWTH-FACTOR BINDING IN AGED RAT CENTRAL NERVOUS-SYSTEM - EFFECT OF ACETYL-L-CARNITINE [J].