KETOCONAZOLE-MEDIATED GROWTH-INHIBITION IN BOTRYTIS-CINEREA AND SACCHAROMYCES-CEREVISIAE

被引：30

作者：

QUAIL, MA

ARNOLDI, A

MOORE, DJ

GOOSEY, MW

KELLY, SL

机构：

[1] UNIV SHEFFIELD,KREBS INST BIOMOLEC RES,DEPT MOLEC BIOL & BIOTECHNOL,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

[2] UNIV MILAN,DIPARTIMENTO SCI MOLEC AGROALIMENTARI,SEZIONE CHIM,I-20122 MILAN,ITALY

[3] SHELL RES LTD,SITTINGBOURNE RES CTR,SITTINGBOURNE ME9 8AG,KENT,ENGLAND

来源：

PHYTOCHEMISTRY | 1993年 / 32卷 / 02期

关键词：

BOTRYTIS-CINEREA; SACCHAROMYCES-CEREVISIAE; KETOCONAZOLE; FUNGICIDE; STEROLS;

D O I：

10.1016/S0031-9422(00)94980-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Minimum inhibitory concentrations (MIC) for Botrytis cinerea and Saccharomyces cerevisiae with ketoconazole were 10 mug ml-1, and 20 mug ml-1, respectively. The time-course of inhibition with treatment at the MIC was examined for each organism and the sterol profile determined. Botrytis cinerea initially accumulated 24-methylene-24(25)-dihydrolanosterol and then obtusifolione during growth arrest. Saccharomyces cerevisiae initially accumulated lanosterol with subsequent production of 3,6 diol, just prior to growth arrest.

引用

页码：273 / 280

页数：8

共 16 条

[1] INHIBITION OF ERGOSTEROL BIOSYNTHESIS IN SACCHAROMYCES-CEREVISIAE AND USTILAGO-MAYDIS BY TRIDEMORPH, FENPROPIMORPH AND FENPROPIDIN [J].