PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE ENHANCES RAPID EYE-MOVEMENT SLEEP IN RATS

被引：24

作者：

FANG, JD ^{[1
]}

PAYNE, L ^{[1
]}

KRUEGER, JM ^{[1
]}

机构：

[1] UNIV TENNESSEE,CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS,MEMPHIS,TN 38163

来源：

BRAIN RESEARCH | 1995年 / 686卷 / 01期

关键词：

REM SLEEP; PACAP; TEMPERATURE; SLEEP; RAT; EEG;

D O I：

10.1016/0006-8993(95)00443-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family, was tested for its effects on sleep in adult male Sprague-Dawley rats. PACAP was injected via intracerebro-ventricular cannula at light or dark onset; sleep and brain temperature (Tbr) were recorded for 12 h after injection. Rapid eye movement sleep (REMS) was significantly enhanced by 30 pmol, but not 3 or 300 pmol PACAP injected at dark onset. Non-REMS was not influenced by 3, 30, or 300 pmol PACAP Sleep and Tbr were not influenced by 3 or 30 pmol PACAP injected at light onset.

引用

页码：23 / 28

页数：6

共 44 条

[1] TISSUE DISTRIBUTION OF PACAP AS DETERMINED BY RIA - HIGHLY ABUNDANT IN THE RAT-BRAIN AND TESTES [J].

ARIMURA, A ;

SOMOGYVARIVIGH, A ;

MIYATA, A ;

MIZUNO, K ;

COY, DH ;

KITADA, C .

ENDOCRINOLOGY, 1991, 129 (05) :2787-2789

[2] INCREASE OF PROLACTIN MESSENGER-RNA IN THE RAT HYPOTHALAMUS AFTER INTRACEREBROVENTRICULAR INJECTION OF VIP OR PACAP [J].

BREDOW, S ;

KACSOH, B ;

OBAL, F ;

FANG, J ;

KRUEGER, JM .

BRAIN RESEARCH, 1994, 660 (02) :301-308

[3]

CHASTRETTE N, 1988, SLEEP PEPTIDES BASIC, P27

[4]

Drucker-Colin R., 1988, SLEEP PEPTIDES BASIC, P73

[5] IS VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) A SLEEP FACTOR [J].

DRUCKERCOLIN, R ;

BERNALPEDRAZA, J ;

FERNANDEZCANCINO, F ;

OKSENBERG, A .

PEPTIDES, 1984, 5 (04) :837-840

[6]

DRUCKERCOLIN R, 1975, NEUROENDOCRINOLOGY, V42, P467

[7]

EHLERS CL, 1986, NEUROENDOCRINOLOGY, V11, P467

[8] DRINKING INDUCED BY INJECTION OF ANGIOTENSIN INTO BRAIN OF RAT [J].

EPSTEIN, AN ;

FITZSIMONS, JT ;

ROLLS, BJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1970, 210 (02) :457-+

[9] DISTRIBUTION, MOLECULAR CHARACTERIZATION OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE AND ITS PRECURSOR ENCODING MESSENGER-RNA IN HUMAN AND RAT-TISSUES [J].

GHATEI, MA ;

TAKAHASHI, K ;

SUZUKI, Y ;

GARDINER, J ;

JONES, PM ;

BLOOM, SR .

JOURNAL OF ENDOCRINOLOGY, 1993, 136 (01) :159-166

[10] PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE, GROWTH-HORMONE (GH)-RELEASING PEPTIDE AND GH-RELEASING HORMONE STIMULATE GH RELEASE THROUGH DISTINCT PITUITARY RECEPTORS [J].

GOTH, MI ;

LYONS, CE ;

CANNY, BJ ;

THORNER, MO .

ENDOCRINOLOGY, 1992, 130 (02) :939-944

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