SYNTHESIS OF SOME HYDROXYMETHYL-AND AMINOMETHYL-INDOLIZINES

被引：28

作者：

JONES, G

STANYER, J

机构：

[1] Chemistry Department, University of Keele, Keele

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 06期

关键词：

D O I：

10.1039/j39690000901

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses are reported of 2-hydroxymethylindolizine (4), 3-hydroxymethylindolizine (5), and 2-methyl-6-hydroxymethylindolizine (6). Attempts to prepare 1-hydroxymethyl-2-methylindolizine by reduction of the corresponding ethoxycarbonyl derivative or by a Chichibabin synthesis from a 2-pyridylethanol derivative were unsuccessful, although 1-(2-hydroxyethyl)-2- methylindolizine (13) was so obtained. The very unstable 2-aminomethylindolizine (15) and 7-aminomethyl-2-methylindolizine (34) have been obtained by reduction of the corresponding nitrites; attempts to obtain 6-aminomethyl-2- methylindolizine are described.

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页码：901 / &

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