EFFECT OF PHENOBARBITONE ON ADULT-RAT LIVER-CELLS IN PRIMARY CULTURE

被引：4

作者：

FRY, JR ^{[1
]}

BRIDGES, JW ^{[1
]}

机构：

[1] UNIV SURREY,INST IND & ENVIRONM HLTH & SAFETY,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

TOXICOLOGY LETTERS | 1979年 / 4卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0378-4274(79)90069-9

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Phenobarbitone (PB) was toxic to rat liver fibroblasts within the concentration range 0.1-10 mM but was toxic to rat hepatocytes only at concentrations greater than 2 mM. This increase in cytotoxicity coincided with a decline in the PB-mediated inducibility of the microsomal monooxygenase (MMO) system. Benzanthracene (BA) was not cytotoxic to either cell type at maximal inducing concentration. Exposure of the cells to a mixture of PB + BA at maximal inducing concentrations produced synergistic toxicity to the fibroblasts, due possibly to PB-mediated induction of BA reactive metabolite formation. © 1979.

引用

页码：295 / 301

页数：7

共 26 条

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