DIFFERENTIAL ENHANCEMENT OF HLA-B27 BY INTERFERON

被引：10

作者：

ABIHANNA, D ^{[1
]}

WAKEFIELD, D ^{[1
]}

机构：

[1] UNIV NEW S WALES,SCH PATHOL,KENSINGTON,NSW 2033,AUSTRALIA

来源：

HUMAN IMMUNOLOGY | 1990年 / 27卷 / 01期

关键词：

D O I：

10.1016/0198-8859(90)90093-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To further examine the role of the HLA-B27 antigen in the pathogenesis of disorders such as anterior uveitis and ankylosing spondylitis, we have measured the level of enhancement of this antigen on peripheral blood lymphocytes and compared it with that of the class I HLA antigens HLA-A2 and HLA-B7 following interferon treatment. We found that the level of enhancement of HLA-B27 was greater than that of HLA-A2 or -B7 following treatment by α or γ interferon (p<0.002). Similarly, the level of enhancement of HLA-B7 was greater than that of HLA-A2 (p<0.002) (Mann Whitney U-test). A differential enhancement of HLA-B27 by lymphokines may be important in the pathogenesis of HLA-B27-related disorders. © 1990.

引用

页码：33 / 39

页数：7

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